Analysis of the correlation between influenza virus infection and Kawasaki disease and the variation levels of peripheral blood cytokines and T lymphocytes in children
OBJECTIVE To investigate the correlation between influenza virus infection and Kawasaki disease,and analyze the variation levels of peripheral blood cytokines and T lymphocytes in children.METHODS Clinical data of children admitted to the People's Hospital in Hengshui City from Oct 2018 to Mar 2023 were retrospective ana-lyzed in the study.32 cases of Kawasaki disease infected with influenza virus included in the combination group,98 cases of Kawasaki disease were included in the Kawasaki disease group,and 102 cases of children infected with in-fluenza virus were included in the influenza virus infection group.Clinical manifestations between the combined group and the Kawasaki disease group,virus types between the combined group and influenza virus infection group,levels of laboratory indexes,peripheral blood cytokines and T lymphocyte among the three groups were compared.RESULTS Compared with the Kawasaki disease group,the incidence of anal skin peeling,coronary ar-tery damage and non-response to injection of gamma globulin were higher in the combined group,and the duration of fever was longer(P＜0.05).Compared with the influenza virus infection group,the proportion of parainfluenza virus type 3 was lower while the proportion of adenovirus was higher in the combined group(P＜0.05).The lev-els of whole blood platelet count(PLT),CD8+,serum interleukin-2(IL-2),C-reactive protein(CRP)and pro-calcitonin(PCT)in the combined group were higher than those in the Kawasaki disease group and the influenza vi-rus infection group(P＜0.05).The levels of alanine aminotransferase(ALT)and amyloid protease A(SAA)in the combination group were higher than those in the influenza virus infection group and the Kawasaki disease group;the levels of ALT and SAA in the influenza virus infection group were higher than those in the Kawasaki disease group(P＜0.05).The levels of whole blood of CD4+,CD4+/CD8+in the combined group were lower than those in the Kawasaki disease group and the influenza virus infection group(P＜0.05).CONCLUSION The virus types in children with Kawasaki disease complicated with influenza were different from those in children only infected with influenza virus.Co-infection with influenza virus could aggravate Kawasaki disease's clinical manifes-tations,and the occurrence of the disease may be related to the disturbance of peripheral blood cytokines and T lymphocytes caused by influenza virus,which could be used as the basis for clinical diagnosis and treatment.
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