Clinical characteristics of 626 cases of drug-resistant pulmonary tuberculosis and mutations of drug resistance genes
OBJECTIVE To analyze the clinical characteristics and mutation of drug-resistant genes in 626 patients with pulmonary tuberculosis.METHODS A total of 626 patients with tuberculosis admitted to Jinyintan Hospital in Wuhan from Jun 2018 to Dec 2022 were included in the study.According to the drug resistance of Mycobacteri-um tuberculosis,the patients were divided into the drug-resistant group(189 cases)and non-drug-resistant group(437 cases).The status of drug resistance,clinical characteristics and the mutation characteristics of drug-resist-ant genes in patients with tuberculosis were analyzed.RESULTS 626 strains of M.tuberculosis were isolated from 626 patients with pulmonary tuberculosis,of which 189 were drug-resistant,with the drug-resistant rate of 30.19％,and 87 were multidrug resistant.Clinical characteristics analysis showed that the age and the rate of re-treatment in the drug-resistant group and the type of retreatment were higher than those in the non-drug-resistant group(P＜0.05).The main mutation of drug resistance genes in tuberculosis patients were katG gene mutation(315 Ser replaced by Thr,mutation rate 38.10％),rpoB gene mutation(521 Ser replaced by Leu,mutation rate 28.04％),and rpsL gene mutation(43 Lys replaced by Arg,mutation rate 26.98％).CONCLUSION The drug re-sistance of M.tuberculosis in tuberculosis patients is not optimistic.The clinical characteristics of drug resistance include age ≥60 years old and retreatment of medical history type.Analysis of the clinical characteristics and mu-tation characteristics of drug resistance genes could provide a basis for the formulation of preventive measures.
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