Predictive value of sICAM-1,miR-155 and miR-141 on hemodialysis complicated with blood flow infection in diabetic nephropathy patients
OBJECTIVE To investigate the predictive value of serum soluble intercellular adhesion molecule-1(sI-CAM-1),micrornA-155(miR-155)and micrornA-141(miR-141)on hemodialysis blood flow infection in diabetic nephropathy(DN)patients and the distribution of pathogenic bacteria.METHODS From Jun 2018 to Sep 2022,119 patients with DN complicated with blood flow infection in the Affiliated Hospital of Jiangnan University were recruited and divided in to the group B,and the 132 DN patients treated in the hospital during the same period without concurrent blood flow infection were in the A group.The expressions of serum sICAM-1,peripheral blood miR-155 and miR-141 were compared between the two groups,and the predictive value of serum sICAM-1,pe-ripheral blood miR-155 and miR-141 alone and in combination in patients with DN undergoing hemodialysis was analyzed by receiver operating characteristic curve(ROC).The distribution of pathogenic bacteria in patients with DN complicated with hemodialysis was analyzed.RESULTS The expression levels of serum sICAM-1,miR-155 and miR-141 in peripheral blood in the group B were higher than those in the group A(P＜0.05).The area under curve(AUC)value of combined detection of serum sICAM-1,miR-155 and miR-141 in peripheral blood on pre-diction was higher than that of the three alone(P＜0.05),and the sensitivity was higher than that of serum sI-CAM-1 and miR-141 in peripheral blood(P＜0.05).The specificity was lower than that of serum sICAM-1 and miR-141 in peripheral blood(P＜0.05).In DN hemodialysis patients complicated with bloodstream infection,gram-negative bacteria accounted for 63.71％,gram-positive bacteria accounted for 33.06％and fungi accounted for 3.23％.CONCLUSION The combination of serum sICAM-1,peripheral blood miR-155 and miR-141 detection has a good predictive value in DN hemodialysis patients complicated with bloodstream infection,and many kinds of main infectious pathogens were detected in DN hemodialysis patients complicated with bloodstream infection.
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