Clinical effect of Huanglian Jiedu decoction on treatment of patients with damp-heat toxic-excess diabetic foot infection
OBJECTIVE To investigate the effect of Huanglian Jiedu decoction on serum level of cytokine and wound healing in patients with damp-heat toxic-excessive diabetic foot infection.METHODS A total of 152 diabetic foot infection patients with damp-heat toxicity syndrome admitted to Nanyang Central Hospital from Aug 2020 to Apr 2023 were divided into the group A and group B by random number table method,with 76 cases in each group.Pa-tients in the group A were treated with conventional methods.Patients in the group B were treated with Huanglian Jiedu decoction on the basis of conventional methods.Both groups were treated for four weeks.The clinical efficacy and wound healing after four weeks of treatment,the score of traditional Chinese medicine syndrome,blood flow dynamics,score of pain and level of serum cytokine before and after treatment were compared between the two groups.RESULTS The total effective rate in the group B after four weeks of treatment was higher than that in the group A(90.79％vs.76.32％,P＜0.05).Compared with before treatment,the wound area in both groups de-creased after 4 weeks of treatment,and compared with the group A,that in the group B was smaller(P＜0.05).The scores of traditional Chinese medicine syndromes,numerical grading system(NRS),levels of serum diamine oxidase(DAO),intercellular adhesion molecule-1(ICAM-1),interleukin-1(IL-1),and IL-6 decreased in both groups,and compared with the group A,the group B was lower(P＜0.05).The diameter and blood flow in the dorsal foot artery increased,and compared with the group A,the diameter in the group B had was larger(P＜0.05).Compared with the group A,coverage area of newly formed granulation tissue in the group B was larger and coverage rate of newly formed granulation tissue was higher after 4 weeks of treatment(P＜0.05).CONCLUSION Huanglian Jiedu decoction could effectively relieve the symptoms of diabetic foot infection in pa-tients with dampness-heat toxic-excess syndrome,promote wound healing,improve the hemodynamics of pa-tients'dorsalis foot,effectively reduce the pain and inflammatory response of patients,and further improve the permeability of patients'intestinal wall,thus improving the therapeutic effect.
Diabetic footInfectionSyndrome of dampness-heat toxicityHuanglian Jiedu decoctionSerum cy-tokineScore of traditional Chinese medicine syndromeDorsalis foot hemodynamicsScore of pain
NETL
NSTL
万方数据
