Value of IL-6 and IL-8 levels in prediction of postoperative infection in lung cancer patients
OBJECTIVE To explore the role of serum interleukin(IL)-6 and IL-8 levels in predicting postoperative infection in lung cancer patients undergoing thoracoscopy radical resection.METHODS A total of 136 lung cancer patients who underwent thoracoscopy radical resection surgery in Zibo First People's Hospital from Jan 2020 to Dec 2022 were recruited.All the patients were divided into the infection group and the uninfected group according to whether nosocomial infection occurred within seven days after surgery.The basic data of the two groups of pa-tients,the levels of serum IL-6 and IL-8 before and after surgery were compared;the independent risk factors af-fecting patients'postoperative infection were analyzed,and the efficacy of IL-6 and IL-8 levels in evaluating post-operative infection was analyzed.RESULTS A total of 21 patients showed symptoms of infection,with a probabili-ty of infection of 15.44％.Patients with infection symptoms in the infection group were older and had longer surgi-cal times.The levels of serum IL-6 and IL-8 of the infected group were higher than those of the uninfected group after surgery for(1 day,3 days)(P＜0.05).Age and surgical time were risk factors for postoperative infection(P＜0.05).The ROC analysis showed that values of areas under the curves of IL-6,IL-8 and their combination were 0.712,0.682,and 0.795,respectively,with statistical significance(P＜0.05).CONCLUSION Age and oper-ation time in lung cancer patients undergoing thoracoscopic radical lung cancer surgery are risk factors for the nos-ocomial infection,and the combined detection of IL-6 and IL-8 levels has a higher predictive value for postopera-tive infection.Clinic should pay more attention.
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