Correlation analysis between high-risk human papillomavirus infection and cervical intraepithelial neoplasia
OBJECTIVE To explore the correlation between high-risk human papillomavirus(HR-HPV)infection and cervical intraepithelial neoplasia(CIN).METHODS A total of 124 CIN patients admitted to the gynecology de-partment of the First People's Hospital of Lianyungang from Jan 2019 to Jan 2023;51 patients with cervical high-grade squamous intraepithelial lesion(HSIL)were divided into the HSIL group,73 patients with cervical low-grade squamous intraepithelial lesion(LSIL)were in the LSIL group.A total of 107 cervical normal patients who were admitted during the same period under routine physical examination(vaginal secretion microecology and HPV genotyping test)were selected as the control group.The differences in the clinical data between the two groups were compared and the correlation between HR-HPV infection and vaginal microecology was analyzed by using a Logistic regression model.RESULTS Multivariate analysis showed that HPV infection,vaginal microecolo-gy and IL-2 were risk factors for the occurrence of LSIL(P＜0.05).Age at first sexual intercourse,HPV infec-tion,vaginal pH,vaginal microecology and IL-2 were risk factors affecting the occurrence of HSIL(P＜0.05).CONCLUSION The occurrence and development of CIN may be related to vaginal microecological abnormalities and HPV infection.
High-risk human papillomavirusInfectionCervical intraepithelial neoplasiaVaginal microecologyCorrelation
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