Clinical characteristics and risk factors of prognosis in neonates with infectious jaundice
OBJECTIVE To analyze the clinical features and prognosis of neonatal infectious jaundice.METHODS A total of 76 children with infectious jaundice who were hospitalized in the Children's Hospital of Wujiang District from Jan 2018 to Jan 2021 were recruited as the observation group.During the same period,70 children with non-infectious jaundice were included in the control group.And the clinical data between the two groups were com-pared.According to the jaundice subsidence time after treatment,the children of the observation group was subdi-vided into the good prognosis group(n=51)and poor prognosis group(n=25).The clinical characteristics in the observation group was analyzed,and the prognostic factors of neonatal infectious jaundice were analyzed by univa-riate and multivariate logistic regression assay.RESULTS A total of 76 strains of pathogenic bacteria were isolated by bacterial culture.Gram-positive bacteria were mainly Staphylococcus aureus,and gram-negative bacteria were mainly Escherichia coli.Serum C-reactive protein(CRP),procalcitonin(PCT),transcutaneous bilirubin(TcB)levels,liver function damage,multiple organ dysfunction(MODS)and the proportion of severe disease in the ob-servation group were higher than those in the control group,while the age of jaundice emergence was smaller than that in the control group,and the proportion of mild disease and neonatal behavioral neurological assessment(NB-NA)scores were lower than those in the control group(P＜0.05).After treatment,the proportion of children with jaundice subsided over five days in the observation group was higher than that in the control group(P＜0.05).The proportion of severe disease and NBNA score in the good prognosis group were lower than those in the poor prognosis group(P＜0.05).Multivariate logistic analysis showed that CRP,PCT,TcB,combined liver function damage,disease severity and NBNA score were all risk factors for poor prognosis of infectious jaundice(P＜0.05).CONCLUSION Compared with children with non-infectious jaundice,children with infectious jaundice have more pronounced inflammatory responses,severer condition,and poorer prognosis.The high expression of serum CRP,PCT,TcB and liver function damage may be related to the poor prognosis of children with infectious jaundice,which should be paid attention to in clinical practice.
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