Diagnostic value of PCT,CRP,NLR,PLR and IgM in peripheral blood on pulmonary infection in children with bronchial asthma
OBJECTIVE To investigate the value of procalcitonin(PCT),neutrophil/lymphocyte ratio(NLR),C-reactive protein(CRP),platelet/lymphocyte ratio(PLR)and immunoglobulin M(IgM)in the diagnosis of bron-chial asthma complicated with pulmonary infection in children.METHODS A total of 166 children diagnosed with bronchial asthma complicated with pulmonary infection in the department of pediatrics of the First Affiliated Hos-pital of Nanyang Medical College from Jan 2022 to Nov 2022 were enrolled as the infection group,which were sub-divided into the bacterial group(118 cases)and mycoplasma group(48 cases)according to the type of pathogenic bacteria detected.And 100 children with simple asthma during the same period were selected as the control group.The clinical symptoms were recorded in detail;the levels of PCT,CRP and IgM in peripheral blood were detec-ted,and NLR and PLR were calculated.Receiver operation characteristic(ROC)curve was used to analyze the di-agnostic value of different indexes on pulmonary infection with different pathogens.RESULTS The proportions of cough,wheezing,fever,shortness of breath,cyanosis and nasal congestion in the bacterial group and mycoplasma group were higher than those in the control group(P＜0.05).The proportions of wheezing,shortness of breath,cyanosis and nasal congestion in the bacterial group were higher than those in the mycoplasma group(P＜0.05),while children aged≥6years,and the proportion of cough was lower than those in the mycoplasma group(P＜0.05).PCT,CRP,NLR,PLR and WBC in the bacterial group were higher than those in the mycoplasma group and control group(P＜0.05),while IgM was lower than that in the mycoplasma group(P＜0.05).CRP,NLR,PLR,WBC and IgM in the mycoplasma group were higher than those in the control group(P＜0.05).The ROC-area under curve(AUC)of PCT,CRP,NLR,PLR and WBC in the combined diagnosis of bacterial infection was 0.881.The ROC-AUC of CRP,NLR,PLR,WBC and IgM in the combined diagnosis of mycoplasma infection was 0.854.CONCLUSION The clinical symptoms of bacterial or mycoplasma pulmonary infection in children with bronchial asthma are different,and the combination of multiple indexes has certain diagnostic value for bacterial or mycoplasma infection.
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