Association of SAA,ChE and Ppv-aCO2 with prognosis of septic shock patients and predictive value
OBJECTIVE To explore the values of peripheral blood serum amyloid A(SAA),cholinesterase(ChE)and peripheral venous arterial carbon dioxide partial pressure difference(Ppv-aCO2)in prediction of poor progno-sis of the patients with septic shock.METHODS A total of 212 patients with septic shock who were treated in Yantai Mountain Hospital in Yantai City from Feb 2021 to Feb 2023 were enrolled in the study,the clinical data were collected from the patients,and the enrolled patients were divided into the favorable prognosis group with 149 cases and the poor prognosis group with 63 cases according to 28-day survival status after the admission to hospital.The clinical data were compared between the two groups of patients,and the values of peripheral blood SAA,ChE and Ppv-aCO2 in prediction of poor prognosis of the septic shock patients were analyzed.RESULTS The patients of the poor prognosis group were significantly elder than those of the favorable prognosis group(P＜0.05).Sequential organ failure assessment(SOFA)score and acute physiology and chronic health evaluation(A-PACHE)Ⅱ score were significantly higher in the poor prognosis group than in the favorable prognosis group(P＜0.05).The SAA level and Ppv-aCO2 of the poor prognosis group were significantly higher than those of the favor-able prognosis group(P＜0.05);the ChE level of the poor prognosis group was significantly lower than that of the favorable prognosis group(P＜0.05).The result of receiver operating characteristic(ROC)curve analysis showed that the area under curve(AUC)of the joint detection of SAA,ChE and Ppv-aCO2 was 0.859 in predic-tion of the poor prognosis of the patients with septic shock,with the sensitivity 76.19％,the specificity 83.89％.CONCLUSION The SAA,ChE and Ppv-aCO2 can be used for assessment of the poor prognosis of the patients with septic shock,and the joint detection of the three indexes has higher predictive value.
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