Association between gastric mucosal tissues,serum markers and Hp infection in patients with chronic gastritis
OBJECTIVE To explore the association between the gastric mucosal tissue microribonucleic acid-22(miR-22),cytotoxin-associated protein A(CagA),serum thioredoxin-1(TRX-1),pepsinogen Ⅱ(PG Ⅱ)and the Helicobacter pylori(Hp)infection in the patients with chronic gastritis.METHODS Totally 90 patients with chronic gastritis who were treated in the First Affiliated Hospital of Nanyang Medical College from Mar 2020 to Mar 2023 were recruited as the research subjects and were divided into the Hp infection group with 29 cases and the no Hp infection group with 61 cases according to the result of Hp test.The result of pathological diagnosis of gastric mucosal tissues,intestinal flora,gastric mucosal tissue miR-22,CagA,serum TRX-1 and PG Ⅱ were ob-served and compared between the two groups of patients.RESULTS The proportions of patients with chronic a-trophic gastritis,inflammatory activity,moderate to severe inflammatory degree,lymphoid follicles formation and epithelial intestinal metaplasia were significantly higher in the Hp infection group than in the no Hp infection group(P＜0.05).The colony counts of Escherichia coli,Lactobacillus and Bifidobacterium of the Hp infection group were significantly less than those of the no Hp infection group(P＜0.05);the colony counts of Lactobacil-lus acidophilus of the Hp infection group were significantly more than those of the no Hp infection group(P＜0.05).The gastric mucosal tissue miR-22 level of the Hp infection group was significantly lower than that of the no Hp infection group(P＜0.05);the levels of gastric mucosal tissue CagA,serum TRX-1 and PG Ⅱ of the Hp infection group were significantly higher than those of the no Hp infection group(P＜0.05).The area under curve(AUC)of the joint detection of gastric mucosal tissue miR-22,CagA,serum TRX-1 and PG Ⅱ was 0.940 in diag-nosis of Hp infection in the patients with chronic gastritis,with the sensitivity 96.55％,the specificity 80.33％.CONCLUSION The Hp infection is associated with the progression of illness condition of the patients with chronic gastritis,it can lead to the disorder of intestinal flora.The chronic gastritis patients with Hp infection show low expression of gastric mucosal tissue miR-22 and high expressions of CagA,serum TRX-1 and PG Ⅱ.
Chronic gastritisHelicobacter pyloriInfectionMicroribonucleic acid-22Thioredoxin-1Cytotox-in-associated protein APepsinogen Ⅱ
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