Etiological characteristics and risk factors for postoperative central nervous system infection in craniocerebral injury patients
OBJECTIVE To investigate the etiological characteristics and risk factors for the postoperative central nervous system infection in the patients with craniocerebral injury.METHODS A total of 630 patients who under-went craniocerebral surgery in Qingdao Haici Hospital Affiliated to Qingdao University from Jan 2018 to Dec 2022 were retrospectively recruited as the research subjects.The prevalence of postoperative central nervous system in-fection and distribution of pathogens were statistically analyzed.Univariate analysis and multivariate logistic re-gression analysis were performed for the risk factors for the postoperative central nervous system infection in the patients with craniocerebral injury.RESULTS Among the 630 patients with craniocerebral injuries,35 had postop-erative central nervous system infection,with the infection rate 5.56％.Totally 37 strains of pathogens were isola-ted,20(54.05％)of which were gram-positive bacteria,16(43.24％)were gram-negative bacteria,1(2.70％)was fungus;coagulase-negative Staphylococcus was dominant among the gram-positive bacteria,Acinetobacter baumannii was the predominant species of the gram-negative bacteria.The operation duration no less than 4 hours,open injury,complication with diabetes mellitus,intraventricular drainage tube indwelling and leakage of cerebrospinal fluid were the independent risk factors for the postoperative central nervous system infection in the patients with craniocerebral injuries(OR=2.212;2.284;2.121;2.071;2.259,P＜0.05).CONCLUSION The incidence of postoperative central nervous system infection is high among the patients with craniocerebral injuries.Coagulase-negative Staphylococcus and A.baumannii are dominant among the isolated pathogens.The risk factors include the operation duration no less than 4 hours,open injury,complication with diabetes mellitus,intraventricular drainage tube indwelling and leakage of cerebrospinal fluid.It is necessary for the hospital to take prevention measures based on the risk factors so as to reduce the risk of postoperative central nervous system in-fection.
Craniocerebral injuryPostoperative infectionCentral nervous system infectionPathogenRisk fac-tor
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