Influence of urogenital system Mycoplasma infection on disease activity and vaginal microecology of patients with systemic lupus erythematosus
OBJECTIVE To explore the influence of urogenital system Mycoplasma infection on the disease activity and vaginal microecology of the patients with systemic lupus erythematosus(SLE).METHODS A total of 62 SLE patients complicated with urogenital system Mycoplasma infection who were treated in Affiliated Hospital of Inner Mongolia Medical University from Jun 2020 to Jun 2023 were assigned as the infection group,and 60 SLE patients who were not complicated with infection were chosen as the no infection group.The clinical characteristics of the patients were analyzed.The vaginal microecology,disease activity,immunoglobulin level and complement level were observed and compared between the two groups of patients.RESULTS The proportion of patients with mi-croecological imbalance was significantly higher in the infection group than in the no infection group(P＜0.05).There were significant differences in density of flora,pH value,catalase activity,sialidase activity and leukocyte esterase activity between the two groups of patients(P＜0.05).The SLE disease activity index score was(21.51±2.42)points in the infection group,(15.42±2.57)points in the no infection group,and there was signifi-cant difference in the SLEDAI score between the two groups(t=8.426,P＜0.001).The antinuclear antibodies(ANA)titers,rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)level and immunoglobulin level were significantly higher in the infection group than in the no infection group(P＜0.05),and the expression level of complement C3 of the infection group was significantly lower than that of the no infection group(P＜0.05).CONCLUSION The Mycoplasma infection may affect the disease activity of the SLE patients and mediate the immune injury and disease activity by affecting the activation level of humoral immunity.
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