原发性肝癌TACE术后医院感染临床特征及microRNA的预测价值
Clinical characteristics of postoperative nosocomial infection in primary liver cancer patients undergoing TACE and predictive value of microRNA
张超 1赵婷 2戴钰辉 1袁泽龙 1吴汝江1
作者信息
- 1. 河北北方学院附属第一医院介入科,河北张家口 075000
- 2. 河北北方学院附属第一医院国际医疗部,河北张家口 075000
- 折叠
摘要
目的 探讨原发性肝癌肝动脉栓塞介入化疗(TACE)术后医院感染的特点及与血清微小核糖核酸(miR)的关系.方法 选取2019年1月-2023年4月于河北北方学院附属第一医院接受T ACE手术治疗的648例原发性肝癌患者,根据是否发生医院感染分为感染组51例和未感染组597例,比较两组患者临床特点和血清miR-200a、miR-15a及miR-221水平,绘制受试者工作特征(ROC)曲线分析血清miR-200a、miR-15a及miR-221对原发性肝癌TACE术后医院感染的预测价值.结果 感染组合并糖尿病、有脾脏栓塞、有侵入性操作患者占比高于未感染组(P＜0.05);感染组血清miR-200a、miR-15a水平低于未感染组(P＜0.05),血清miR-221水平高于未感染组(P＜0.05);ROC曲线分析结果显示,血清miR-200a、miR-15a及miR-221联合检测预测原发性肝癌TACE术后医院感染的曲线下面积(AUC)值为0.917,高于单独预测(P＜0.05).结论 血清miR-200a、miR-15a在原发性肝癌TACE术后医院感染患者中呈低表达,而血清miR-221呈高表达,且合并糖尿病、有脾脏栓塞、有侵入性操作与原发性肝癌TACE术后医院感染有关.
Abstract
OBJECTIVE To explore the characteristics of postoperative nosocomial infection in the primary liver cancer patients undergoing transcatheter arterial chemoembolization(TACE)and analyze the association with ser-um micro ribonucleic acid(miR).METHODS Totally 648 patients with primary liver cancer who received TACE in Hebei North University Affiliated First Hospital from Jan 2019 to Apr 2023 were enrolled in the study and were divided into the infection group with 51 cases and the no infection group with 597 cases according to the status of nosocomial in-fection.The clinical characteristics and levels of serum miR-200a,miR-15a and miR-221 were observed and compared be-tween the two groups of patients.The values of serum miR-200a,miR-15a and miR-221 in prediction of postoperative nosocomial infection in the primary liver cancer patients undergoing TACE were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS The proportion of patients complicated with diabetes mellitus,spleen embolism and invasive procedures of the infection group was significantly higher than that of the no infection group(P＜0.05).The levels of miR-200a and miR-15a of the infection group were significantly lower than those of the no infection group(P＜0.05),while the serum miR-221 level of the infection group was significantly higher than that of the no infection group(P＜0.05).The result of ROC curve analysis showed that the area under curve(AUC)of the joint detection of serum miR-200a,miR-15a and miR-221 was 0.917 in prediction of postoperative nosocomial infection in the primary liver canc-er,higher than that of the single detection(P＜0.05).CONCLUSION The primary liver cancer patients with nosoco-mial infection show low expressions of serum miR-200a and miR-15a after TACE but show high expression of ser-um miR-221.The postoperative nosocomial infection in the primary liver cancer patients undergoing TACE is as-sociated with the diabetes mellitus,spleen embolism and invasive operation.
关键词
原发性肝癌/肝动脉栓塞介入化疗/医院感染/临床特征/微小核糖核酸/预测价值Key words
Primary liver cancer/Transcatheter arterial chemoembolization/Nosocomial infection/Clinical charac-teristic/Microribonucleic acid/Predictive value引用本文复制引用
基金项目
河北省卫生健康委科研项目(20231463)
出版年
2024
NETL
NSTL
万方数据