Distribution of pathogens isolated from open fracture patients with postoperative incision infection and predictive values of serum MCP-1,bFGF and miR-223
OBJECTIVE To explore he distribution of pathogens isolated from the open fracture patients with post-operative incision infection and analyze the predictive values of serum monocyte chemoattractant protein(MCP-1),basic fibroblast growth factor(bFGF)and micro ribonucleic acid(miR)-223.METHODS A total of 96 open frac-ture patients who had postoperative incision infection in Hainan West Central Hospital from Jan 2020 to Jan 2023 were assigned as the study group,meanwhile,96 open fracture patients who did not have postoperative incision infection were chosen as the control group.The distribution of pathogens isolated from the open fracture patients with postoperative incision infection was observed,multivariate logistic regression analysis was performed for the risk factors for the postoperative incision infection,and the values of MCP-1,bFGF and miR-223 in diagnosis of postoperative incision infection were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Totally 96 strains of pathogens were isolated from the 96 open fracture patients with postoperative in-cision infection,52(54.17％)of which were gram-positive bacteria,40(41.67％)were gram-negative bacteria,and 4(4.17％)were fungi.The more than 60 years of age,interval between injury and admission no less than 6 hours,operation duration no less than 3 hours,depth of wound no less than 2 cm,length of hospital stay no less than 4 weeks,diabetes mellitus,type Ⅱ-Ⅲ incision surgery and high level of CRP were the risk factors for the postoperative incision infection.The levels of MCP-1 and miR-223 of the study group were significantly higher than those of the control group(P＜0.05),the bFGF level of the study group was significantly lower than that of the control group(P＜0.05).The result of ROC curve analysis showed that the area under curve(AUC)of the joint detection of the three indexes was 0.926 in diagnosis of the postoperative incision infection.CONCLUSION Staphylococcus aureus,Staphylococcus epidermidis,Escherichia coli and Pseudomonas aeruginosa are dominant among the pathogens isolated from the open fracture patients with postoperative incision infection.There are a variety of risk fac-tors for the postoperative incision infection.The patients with the postoperative infection show the rise of MCP-1,miR-223 and the decline of bFGF.The joint detection of the three indexes has high diagnostic value.
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