Distribution of pathogenic bacteria and risk factors for postoperative incision infection in limb fracture patients
OBJECTIVE To explore the distribution of pathogens and risk factors for postoperative incision infection in the limb fracture patients.METHODS The clinical data were retrospectively collected from 3 987 patients with limb fracture who were treated in Shandong University Qilu Hospital(Qingdao)from Jan 2021 to Dec 2022.The patients were divided into the infection group with 158 cases and the non-infection group with 3 829 cases accord-ing to the status of postoperative incision infection.The distribution of pathogens isolated from the infection group was statistically analyzed,and logistic regression analysis was performed for the risk factors for the postoperative incision infection in the patients with limb fracture.RESULTS Among the 3 987 patients with limb fracture,158 had postoperative incision infection,with the incidence rate 3.96％.A total of 158 strains of pathogens were isola-ted,64(40.51％)of which were gram-negative bacteria,90(56.96％)were gram-positive bacteria,and 4(2.53％)were fungi.The expression levels of interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)were significantly elevated after the infection.The result of multivariate logistic analysis showed that com-plication with diabetes mellitus,use of steel plate,operation duration more than 3 hours,open fracture and long length of incision were the risk factors for the postoperative incision infection in the patients with limb fracture(P＜0.05).CONCLUSION The gram-positive bacteria are dominant among the pathogens isolated from the limb fracture patients with postoperative incision infection.The patients with the infection show the rise of inflam-matery factors IL-6,PCT and CRP.The incidence of the postoperative incision infection is closely associated with the diabetes mellitus,use of steel plate,operation duration,open facture,incision,serum IL-6,PCT and CRP.It is necessary for the hospital to take targeted prevention and treatment measures based on the factors so as to re-duce the risk of postoperative incision infection in the patients with limb fracture.
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