Values of serum miR-122a,MIF and HMGB1 in prediction of liver injury in children with sepsis
OBJECTIVE To explore the values of serum micro ribonucleic acid(miR)-122a,melanogen inhibiting factor(MIF)and high mobility group protein B1(HMGB1)in prediction of liver injury in the children with sep-sis.METHODS A total of 93 sepsis children who were complicated with liver injury and were treated in the Third People's Hospital of Haikou City from Jan 2016 to Sep 2023 were assigned as the liver injury group,and 208 chil-dren who were not complicated with liver injury were assigned as the non-liver injury group.The baseline data were collected from the children.Pearson correlation analysis was performed for the association between the levels of miR-122a,MIF and HMGB1 and the acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)score,as-partate transaminase(AST),alanine aminotransferase(ALT),C3 and C4 levels.The values of miR-122a,MIF and HMGB1 in diagnosis of liver injury in the spies children were analyzed by means of receiver operating charac-teristic(ROC)curves.RESULTS The APACHEⅡ score,AST level and ALT level of the liver injury group were sig-nificantly higher than those of the non-liver injury group(P＜0.05),the levels of C3 and C4 of the liver injury group were significantly lower than those of the non-liver injury group(P＜0.05).The levels of miR-122a,MIF and HMGB1 of the liver injury group were significantly higher than those of the non-liver injury group(P＜0.05);the more severe the liver injury,the higher the levels of the indexes(P＜0.05).The result of Pearson correlation analysis showed that the miR-122a,MIF and HMGB1 were positively correlated with the APACHEⅡ score,AST and ALT(P＜0.05)but were negatively correlated with the C3 and C4(P＜0.05).The area under curve(AUC)of the joint detection of miR-122a,MIF and HMGB1 was 0.916 in diagnosis of the liver injury in the sepsis children,with the sensitivity 89.25％,the spe-cificity 80.029％.CONCLUSION The sepsis children with liver injury show the high expressions of miR-122a,MIF and HMGB1,and the three indexes are associated with the APACHEⅡ score,AST,ALT,C3 and C4.
SepsisLiver injuryMicro ribonucleic acid-122aMelanogen inhibiting factorHigh mobility group protein B1Predictive valueRisk factor
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