Pathogenesis mechanisms of NF-κB/NLRP3/Caspase-1 signaling pathways in rheumatoid arthritis patients complicated with infection
OBJECTIVE To explore the pathogenic mechanisms of nuclear factor-κB(NF-κB)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)/caspase-1 signaling pathways in the infection of the pa-tients with rheumatoid arthritis(RA).METHODS A total of 80 RA patients who were complicated with infection and treated in Tianjin First Central Hospital from Jun 2021 to Jun 2023 were assigned as the infection group,and 80 RA patients who were not complicated with infection were assigned as the no infection group.Meanwhile,80 healthy people who received physical examination were chosen as the control group.The types of the infection were analyzed,the levels of peripheral blood NF-κB,NLRP3,caspase-1,interleukin(IL)-1β and IL-18 were detected for the three groups of participants.The values of NF-κB,NLRP3 and Caspase-1 in diagnosis of the infection were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Urinary tract infection and skin infection were the major types of nosocomial infection among the 80 RA patients,accounting for 37.50％and 36.25％,respectively.The levels of NF-κB,NLRP3,Caspase-1,IL-1β and IL-18 of the infection group were higher than those of the no infection group and the control group(P＜0.05),and the levels of the above indexes of the no infection group were significantly higher than those of the control group(P＜0.05).The ROC curve a-nalysis showed that NF-κB,NLRP3 and Caspase-1 had high diagnostic efficiencies for infection in the RA pa-tients,and the areas under curves(AUCs)were 0.934,0.817 and 0.821,respectively.CONCLUSION The abnor-mal activation of NLRP3/Caspase-1 signaling pathways may promote the release of inflammatory factors IL-1β and IL-18 and aggravate the immune-inflammatory response.The indexes can serve as potential diagnostic markers for the infection in the RA patients.
Rheumatoid arthritisInfectionNuclear factor-κBNOD-like receptor thermal protein domain associ-ated protein 3Caspase-1Pathogenesis
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