Effect of Tanreqing injection on treatment of thoracic surgery department patients with postoperative pulmonary infection and impact on serum sCD14,sTREM-1 and CRP
OBJECTIVE To explore the effect of Tanreqing injection on treatment of the thoracic surgery department patients with postoperative pulmonary infection and observe the influence on serum soluble leukocyte differentia-tion antigen 14(sCD14),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and C-reactive pro-tein(CRP).METHODS A total of 120 patients who were treated in thoracic surgery department of Hebie Provin-cial Hospital of Traditional Chinese Medicine and had postoperative pulmonary infection from Jan 2020 to Apr 2023 were enrolled in the study and were randomly divided into the control group with 60 cases and the study group.The control group was given conventional anti-infection therapy,and the study group was given additional Tanreqing injection on basis of the treatment of the control group,both groups were treated for 2 weeks.The clin-ical therapeutic effects and improvement of symptoms and signs were observed after the treatment for 2 weeks,the lung function indexes,serum sCD14,sTREM-1 and CRP were observed and compared between the two groups of patients,and the safety during the treatment was analyzed.RESULTS The total effective rate of the study group was 88.33％after the treatment for 2 weeks,significantly higher than 71.67％of the control group(P＜0.05).The disappearance time of cough and expectoration,lung rales,fever and inflammatory lesions on chest CT were signifi-cantly shorter in the study group than in the control group(P＜0.05).The forced vital capacity(FVC),forced expirato-ry volume in the first second(FEV1)and FEV1/FVC of the study group rose more significantly than those of the control group(P＜0.05);the levels of serum sCD14,sTREM-1 and CRP of the study group declined more significantly than those of the control group(P＜0.05).There was no case of adverse reactions such as chest distress,nausea or emesis in the study group and the control group during the treatment.CONCLUSION Tanreqing injection may effectively regu-late the levels of serum sCD14,sTREM-1 and CRP of the thoracic surgery department patients with postoperative pulmonary infection,alleviate the inflammatory response and boost the lung function so as to improve the symp-toms and signs of the patients,with the curative effect favorable,the safety high.
Thoracis surgery departmentPulmonary infectionTanreqing injectionSymptom and signSoluble leukocyte differentiation antigen 14Soluble triggering receptor expressed on myeloid cells-1C-reactive protein
NETL
NSTL
万方数据
