Changes of Th1/Th2 and their cytokines in peripheral blood of breast cancer chemotherapy patients with PICC-associated bloodstream infection
OBJECTIVE To observe the changes of helper T cell(Th)1/Th2 and their cytokines in peripheral blood of the breast cancer chemotherapy patients with peripherally inserted central catheter(PICC)-associated blood-stream infection.METHODS The breast cancer patients who were treated with PICC and underwent chemotherapy in Shanxi Yuncheng Central Hospital from Jan 2020 to 2022 were recruited as the research subjects.According to the status of PICC-associated bloodstream infection,36 patients were randomly assigned as the infection group,and 114 patients were assigned as the no infection group.The levels of peripheral blood Th1/Th2,Th1 type cyto-kines[interleukin(IL)-2,tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)]and Th2 type cytokines(IL-4,IL-6,IL-10)were observed and compared between the two groups of patients.The values of the peripheral blood Th1/Th2,IL-2,TNF-α,IFN-γ,IL-4,IL-6 and IL-10 in prediction of PICC-associated bloodstream infection were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS There were significant differences in the catheter indwelling time and number of times of chemotherapy between the two groups(P＜0.05).The levels of TNF-α,IL-4,IL-6 and IL-10 of the infection group were significantly higher than those of the no infec-tion group(P＜0.05),the levels of Th1/Th2,IL-2 and IFN-γ of the infection group were significantly lower than those of the no infection group(P＜0.05).ROC curve analysis showed that the areas under curves(AUCs)of the peripheral blood Th1/Th2,IL-2,TNF-α,IFN-γ,IL-4,IL-6 and IL-10 were respectively 0.896,0.803,0.944,0.649,0.744,0.978 and 0.946 in prediction of PICC-associated bloodstream infection in the breast cancer pa-tients undergoing chemotherapy.CONCLUSION The PICC-associated bloodstream infection in the breast cancer patients undergoing chemotherapy may be associated with the imbalance of peripheral blood Th1/Th2.
Breast cancerCatheter-associated infectionPeripherally inserted central catheterBloodstream infec-tionHelper T cell
NETL
NSTL
万方数据
