Risk factors for postoperative intracranial infection in patients undergoing transnasal skull base tumor surgery and direct economic loss
OBJECTIVE To investigate the risk factors for postoperative intracranial infection in the patients under-going transnasal skull base tumor surgery and analyze the direct economic loss.METHODS Totally 385 patients who underwent transnasal skull base tumor surgery in neurosurgery department of Beijing Tiantan Hospital,Cap-ital Medical University from Jan 2022 to Jun 2022 were recruited as the research subjects and were divided into the infection group and the non-infection group according to the status of postoperative intracranial infection.Multiva-riate logistic regression analysis was performed for the risk factors for the postoperative intracranial infection.A 1∶1 ratio matching case-control study was conducted by taking the age and sex as the matching factors.The infec-tion-induced direct economic loss and length of hospital stay were compared between the two groups.RESULTS A-mong the 385 patients who underwent the transnasal skull base tumor surgery,totally 33 had postoperative in-tracranial infection,with the incidence of intracranial infection 8.57％.Multivariate logistic regression analysis showed that ventriculoperitoneal shunt,porcine fibrin binder,external ventricular drainage tube and operation du-ration were the risk factors for the postoperative intracranial infection(P＜0.05).The total hospitalization cost of the infection group was 19951.95 yuan more than that of the non-infection group(P＜0.05).Among all the costs,the median difference value of the antibiotic cost was the highest,and the cost of antibiotics of the infection group was 9828 yuan more than that of the non-infection group(P＜0.05).The postoperative length of hospital stay of the infection group was significantly longer than that of the non-infection group,and the medial length of hospital stay was increased by 5 days(P＜0.05).CONCLUSION Ventriculoperitoneal shunt,porcine fibrin binder and ex-ternal ventricular drainage tube are the risk factors for the postoperative intracranial infection in the patients under-going transnasal skull base tumor surgery,and it is necessary to remove the implants as early as possible by strict-ly following the indications.The infection can lead to a significant increase of direct economic loss and extension of length of hospital stay.
Skull base tumorTansnasal skull base tumor surgeryPostoperative infectionNeuroendoscopeIn-tracranial infectionRisk factorEconomic loss
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