Risk factors for severe condition in children with lower respiratory tract influenza virus infection and association with CD226 gene polymorphisms
OBJECTIVE To investigate the risk factors for severe illness condition in the children with lower respira-tory tract influenza virus infection and analyze the association with CD226 gene polymorphisms.METHODS A total of 116 children with lower respiratory tract influenza virus infection who were treated in Hengshui People's Hospital from Jul 2020 to Apr 2023 were assigned as the study group,51 of which had severe lower respiratory tract influenza virus in-fection were assigned as the severe group,and 65 had mild lower respiratory tract influenza virus infection were assigned as the mild group.Meanwhile,138 healthy children who matched the age and gender and received physical examination were chosen as the control group.Logistic regression analysis was performed for the risk factors for the severe lower re-spiratory tract influenza virus infection.The CD226 gene polymorphisms of the enrolled research subjects were detected by means of polymerase-chain-reaction-restriction-fragment-length polymorphism(PCR-RFLP).RESULTS The little age,season of autumn and winter,complication with underlying disease,outdoor activities less than 1.5 h/d and dietary bias were the independent risk factors for the severe lower respiratory tract influenza virus infection(OR=2.210,2.259,2.330,2.079 and 2.212,P＜0.05).The frequencies of CC genotype and G allele at rs727088 lo-cus of CD226 gene were significantly higher in the study group than in the control group(P＜0.05),and the fre-quencies of GG genotype and G allele at rs727088 locus of CD226 gene were significantly higher in the severe group than in the mild group(P＜0.05).CONCLUSION The little age,season of autumn and winter,underlying dis-ease,outdoor activities less than 1.5 h/d and dietary bias are the independent risk factors for the severe lower re-spiratory tract influenza virus infection.There is also association between the CD226 gene polymorphisms and the severity of lower respiratory tract influenza virus infection in the children.
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