Correlation of HBV RNA with hepatitis B virological markers and liver function indexes in chronic HBV-infected patients
OBJECTIVE To investigate the correlation between serum HBV RNA and hepatitis B virological mark-ers and liver function inflammatory indexes in the natural course of disease in chronic hepatitis B virus(HBV)in-fected patients.METHODS A total of 221 patients with chronic HBV infection admitted to the outpatient depart-ment and inpatient department of Hangzhou Xixi Hospital affiliated to Zhejiang Chinese Medicine University from Jun.2022 to Jun.2023 were selected,and none of these patients received ant-iviral treatment,including 168 pa-tients with HBeAg-positive and 53 patients with HBeAg-negative,and quantitative serum HBV RNA was detec-ted to observe its changes in the natural course of different diseases,and its correlation with HBV DNA,HBsAg,HBeAg,ALT,AST and GGT was analyzed.RESULTS The HBV RNA,HBV DNA,HBsAg,HBeAg,ALT,AST and GGT of HBeAg-positive patients were significantly higher than those of HBeAg-negative patients,while the albumin level of HBeAg-positive group was lower than that of HBeAg-negative group(P＜0.05).Serum HBV RNA was positively correlated with HBV DNA(r=0.710),HBsAg(r=0.526)and HBeAg(r=0.373)in the HBeAg positive group.In HBeAg negative group,serum HBV RNA was positively correlated with HBV DNA(r=0.843),HBsAg(r=0.566),ALT(r=0.610),AST(r=0.626),and GGT(r=0.464).CONCLUSION Ser-um HBV RNA was strongly and moderately correlated with HBV DNA and HBsAg,which was presented in both HBeAg-positive and HBeAg-negative patients.Serum HBV RNA was moderately correlated with ALT,AST and GGT,but this correlation was only presented in HBeAg-negative patients.The patient's anti-HBV immune re-sponse could effectively inhibit HBV replication by clearing the infected hepatocytes,whereas the patient's immune response was more related to the inflammatory damage of the liver tissue.
Chronic hepatitis BHBV RNAHBV DNAHepatitis B surface antigenImmune response
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