Expressions of miR-146a,miR-127 and miR-21 in elderly patients with severe pneumonia and their predictive value
OBJECTIVE To investigate the expression levels of serum micrornas(miR-146a),miR-127 and miR-21 levels in elderly patients with severe pneumonia and their predictive value.METHODS A total of 110 elderly pa-tients with severe pneumonia(severe pneumonia group),120 patients with common pneumonia(common pneu-monia group)and 120 healthy physical examination subjects(healthy group)admitted to the Third People's Hos-pital of Haikou City from Nov.2020 to Nov.2022 were selected,serum levels of miR-146a,miR-127 and miR-21 were compared among all subjects,the distribution of pathogenic bacteria in severe pneumonia group was ana-lyzed.Patients with severe pneumonia were divided into survival group(79 cases)and death group(31 cases),the risk factors of death in elderly patients with severe pneumonia were analyzed,and the diagnostic value of serum miR-146a,miR-127 and miR-21 for mortality in elderly patients with severe pneumonia was analyzed.RESULTS Compared with the healthy group,the serum levels of miR-146a,miR-127,and miR-21 were higher in the general pneumonia and the severe pneumonia groups,and those in the severe pneumonia group was higher than those in the general pneumonia group(P＜0.05).A total of 110 strains of pathogenic bacteria were co-cultured and isolated from elderly patients with severe pneumonia,of which 86 strains of gram negative bacteria accounted for 78.18％,20 strains of gram positive bacteria accounted for 18.18％,and 4 strains of fungi accounted for 3.64％.Mechanical ventilation,miR-146a,miR-127,and miR-21 were the risk factors for mortality in elderly patients with severe pneumonia(OR=2.421,1.237,2.467,2.519,P＜0.05).The cvrea unde curve AUC values of miR-146a,miR-127,and miR-21 alone were lower than those of the combined detection of death in elderly patients with severe pneumonia(P＜0.05).CONCLUSION Elderly patients with severe pneumonia had higher serum miR-146a,miR-127 and miR-21 levels and a higher proportion of infections with gram-negative bacteria.Mechanical ventilation,serum miR-146a,miR-127,and miR-21 were risk factors for death in elderly patients with severe pneumonia,and the combined detection of serum miR-146a,miR-127 and miR-21 levels had high value in diagnosing death in eld-erly patients with severe pneumonia.
Severe pneumoniaOld ageMicroRNA-146aMicroRNA-127MicroRNA-21Receiver operating characteristic curve
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