Nutritional status of MHD patients with chronic renal failure and association of their SP-D and HLA genes polymorphisms with pulmonary infections
OBJECTIVE To analyze the nutritional status and the association of surfactant-associated protein D(SP-D)and human leukocyte antigen(HLA)genes polymorphisms with pulmonary infections in patients with chronic renal failure after maintenance hemodialysis(MHD).METHODS A total of 96 patients with chronic renal failure undergoing MHD were selected as the research subjects between Oct.2019 and Feb.2021,and were divided into the infection group and non-infection group according to whether the patients had pulmonary infection or not,with 45 and 51 cases,respectively.The nutritional status of patients was evaluated by modified quantitative subjective global assessment(MQSGA),serum albumin and calcium-phosphorus levels,and the distribution of SP-D and HLA genes polymorphisms were detected.RESULTS MQSGA score,phosphorus level and frequency of HLA-A*0101 allele in infection group were higher than those in non-infection group,while levels of albumin and calcium,frequencies of HLA-B*5201 and HLA-DRBⅠ*1502 alleles were lower than those in non-infection group(P＜0.05).The differences in genotypes and alleles distribution of SP-D gene at rs721917 locus between infection group and non-infection group were statistically significant(P＜0.05).Among patients with pulmonary infection,MQS-GA score of the mild group was lower than that of the moderate-severe group,while the albumin level,frequen-cies of HLA-B*5201 and HLA-DRBⅠ*1502 alleles were higher than those of the moderate-severe group(P＜0.05).CONCLUSION The nutritional status in MHD patients with pulmonary infections and chronic renal failure is poor,and its occurrence and development are closely related to the polymorphisms of SP-D and HLA genes.
Chronic renal failureMaintenance hemodialysisPulmonary infectionNutritional statusSurfactant-associated protein DHuman leukocyte antigen
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NSTL
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