Clinical effect of modified Buzhong Yiqi decoction on trentment elderly patients with pulmonary infection
OBJECTIVE To investigate the effect of modified Buzhong Yiqi decoction on serum soluble myeloid cell triggering receptor-1(sTREM-1),high mobility group protein B1(HMGB1),infection-γ(IFN-γ),procalcitonin(PCT)levels in elderly patients with pulmonary infection.METHODS Totally 98 elderly patients with pulmonary infection admitted to Hengshui city hospital of traditional Chinese medicine from Apr.2020 to Apr.2023 were ran-domly divided into the control group(49 cases)and the experimental group(49 cases),and the group using a ran-dom number table method.The control group was treated with conventional Western medicine,while the experi-mental group was treated with Buzhong Yiqi decoction on this basis.Both groups were treated for 2 weeks.The ef-ficacy after 2 weeks of treatment,symptoms and signs improvement,traditional Chinese medicine symptoms,dis-ease scores,blood gas and inflammation index levels were compared between the two groups before and after 2 weeks of treatment.RESULTS After 2 weeks of treatment,the therapeutic effect of the experimental group was better than that of the control group(P＜0.001);compared with the control group,the recovery time of symp-toms and signs in the experimental group was shorter(P＜0.05),after 2 weeks of treatment compared with be-fore,the traditional Chinese medicine symptoms,clinical pulmonary infection score(CPIS),acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)scores,arterial partial pressure of carbon dioxide(PaCO2),and serum sTREM-1,HMGB1,IFN-γ,and PCT levels in both decreased,experimental group was lower(P＜0.05),the blood saturation oxygen(SaO2),arterial partial pressure of oxygen(PaO2),and oxygenation index(OI)in-creased,experimental group was higher(P＜0.05).CONCLUSION Buzhong Yiqi decoction could regulate the elderly patients with pulmonary infection serum sTREM-1,HMGB1,IFN-y,PCT levels,reduce the body inflam-mation,improve symptoms of traditional Chinese medicine symptoms and blood gas,then alleviate the patient's condition,promote the improvement of clinical symptoms and improve clinical efficacy.
Pulmonary infectionOld ageBuzhong Yiqi decoctionTraditional Chinese medicine symptomsBlood gasSoluble myeloid cell triggered receptor-1High mobility group protein B1Interferon-yProcalcitonin
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