Serum Hcy,Ghrelin and MMP-9 levels in coronary heart disease patients with Hp infection
OBJECTIVE To investigate the levels of serum homocysteine(Hcy),Ghrelin and matrix metalloprotein-ase-9(MMP-9)in coronary heart disease(CHD)patients with Helicobacter pylori(Hp)infection.METHODS Clinical data of 167 patients with coronary heart disease admitted to Nanyang First People's Hospital from Apr.2021 to Apr.2023 were retrospectively analyzed,and they were divided into the infected group(58 cases)and the non-infected group(109 cases)according to whether the patients had Hp infection.Serum Hcy,Ghrelin and MMP-9 levels were detected by enzyme-linked immunosorbent assay.The expression levels of serum Hcy,Ghre-lin,MMP-9 and the degree of coronary artery disease were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of Hcy,Ghrelin and MMP-9 alone and in combination for Hp infection in patients with coronary heart disease.RESULTS Serum Hcy and MMP-9 levels in the infected group were higher than those in the non-infected group(P＜0.05),while Ghrelin levels were lower than those in the non-infected group(P＜0.05).The area under the curve(AUC)of Hey,Ghrelin and MMP-9 alone and in combination for the diagnosis of Hp infection were 0.825,0.808,0.770 and 0.929,respectively.Of which,the AUC of the combined diagnosis was higher than that of the single detection,and the sensitivity and specificity of combined detection were 82.80％and 88.10％.The proportion of patients with mild coronary artery disease in the infection group was lower than that in the non-infection group(P＜0.05),while the proportion of patients with moderate and severe coronary artery disease was higher than that the in non-infection group(P＜0.05).CONCLUSION The expression of Hcy and MMP-9 were increased and the expression of Ghrelin was de-creased in patients with CHD after Hp infection.Combined detection of Hcy,Ghrelin and MMP-9 is helpful for the diagnosis of HP infection in patients with coronary heart disease.
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