Glycolipid metabolism and plaque characteristics in patients with coronary heart disease combined with Hp infection and miR-146a,IL-33 and ST2 levels
OBJECTIVE To investigate the effects of coronary heart disease complicated with Helicobacter pylori(Hp)infection on glycolipid metabolism and plaque characteristics,microRNA-146a(miR-146a),interleukin 33(IL-33)and suppression of tumorigenicity 2(ST2).METHODS Eighty six patients with simple coronary heart dis-ease(without Hp infection)admitted to the First People's Hospital of Shangqiu from Jun.2018 to Jun.2022 were selected as the un-infection group,and 60 patients with coronary heart disease complicated with Hp infection trea-ted in this hospital during the same period were selected as the infection group.Glucose metabolism related indica-tors[fasting blood glucose,glucagon,glucagon-like peptide-1(GLP-1),somatostatin(SS)and insulin],lipid metabolism related indicators[triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)],plaque characteristics,and the levels of miR-146a,serum IL-33 and ST2 were compared between the two groups and among patients with different severity of infec-tion.RESULTS Fasting blood glucose,glucagon,TG and TC in the infection group were higher than those in the un-infection group,while SS and HDL-C were lower than those in the un-infection group(P＜0.05).The carotid intima-media thickness(IMT)and plaque area of the infection group were larger than those of the un-infection group(P＜0.05).The infection group had fewer mixed and hard plaques,and more soft plaques than the un-in-fection group(P＜0.05).The levels of miR-146a,serum IL-33 and ST2 in the infection group were higher than those in the un-infection group(P＜0.05).With the aggravation of Hp infection in patients with coronary heart disease,the levels of miR-146a,serum IL-33 and ST2 increased(P＜0.05).CONCLUSION Hp infection can lead to the emergence of disturbances in glycolipid metabolism,decreased plaque stability,and elevated levels of miR-146a,serum IL-33 and ST2 in patients with coronary heart disease,which promote disease progression.
Coronary heart diseaseHelicobacter pyloriPlaque characteristicMiR-146aInterleukin-33Sup-pression of tumorigenicity 2
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