Risk factors for hospital-acquired infections in patients with myelodysplastic syndrome and its predictive model evaluation
OBJECTIVE To investigate the risk factors for hospital-acquired infections in patients with myelodys-plastic syndrome(MDS)and its predictive model evaluation.METHODS Totally 548 patients with MDS admitted to Nanyang Second People's Hospital from Apr.2021 to Feb.2023 were selected as the research subjects,and were divided into the infected group(102 cases)and the non-infected group(446 cases)according to the occurrence of hospital-acquired infection.The status of hospital-acquired infection and clinical data in patients with MDS was an-alyzed,the risk factors of hospital-acquired infection in patients with MDS were analyzed by logistic regression a-nalysis,and the nomogram prediction model and logistic regression model were constructed,and receiver operat-ing characteristic curve(ROC)was plotted to analyze the predictive value of the model in MDS complicated with hospital-acquired infection.RESULTS Invasive procedures,duration of antibiotic use,and chromosomal karyotype were the risk factors for hospital-acquired infections in MDS patients(P＜0.05),while absolute counts of bone marrow progenitor cells and neutrophils(ANC)were protective factors for hospital-acquired infections in MDS pa-tients(P＜0.05);The 5 factors screened by the above model were included in the model to construct a nomogram model for the occurrence of hospital-acquired infections in MDS patients,and the Hosmer Lemeshow fit test showed that x2=4.453,P=0.616,and the accuracy of model fitting was good.The above factors were included in the multivariate logistic prediction model:logit(P)=-0.864+invasive operations × 0.678+antibacterial drug usage time × 0.735-Bone marrow primitive cells × 0.826-ANC × 1.129+chromosomal karyotype× 2.222.The ROC curve was plotted,and the results showed that when logit(P)＞0.176,the area under the curve(AUC)was 0.911,the diagnostic sensitivity was 83.33％,and the specificity was 85.65％.CONCLUSION The occurrence of hospital-acquired infection in patients with MDS was 18.61％was closely related to a variety of factors,and the value of the predictive model to predict hospital-acquired infection in patients with MDS was high,which allowed for early screening of high-risk patients and preventive interventions.
Myelodysplastic syndromeHospital-acquired infectionStatusRisk factorModelPredictive value
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