TLR7 mRNA,IL-23 and IL-17 in patients with hypertensive cerebral hemorrhage complicated with pulmonary infection and their predictive value
OBJECTIVE To investigate Toll-like receptor 7(TLR7),interleukin-23(IL-23)and IL-17 in patients with hypertensive cerebral hemorrhage(HCH)complicated with pulmonary infection and their predictive value.METHODS The clinical data of 387 patients with HCH admitted to the Central People's Hospital of Ji'an,Jiangxi Province from Jan.2020 to May 2022 were retrospectively collected,and the patients were divided into an infected group(77 cases)with pulmonary infection and a non-infected group(310 cases)without pulmonary infection.The levels of serum TLR7,IL-23 and IL-17 signaling pathway indicators were compared between the two groups,and the risk factors of HCH patients complicated with pulmonary infection were summarized.The predictive value of serum TLR7 messenger ribonucleic acid(mRNA),IL-23 and IL-17 for HCH patients complicated with pulmona-ry infection were analyzed.RESULTS The levels of TLR7 mRNA,IL-17 and IL-23 in the infected group were higher than those in the uninfected group(P＜0.05).Smoking history,chronic obstructive pulmonary disease,Glasgow coma scale(GCS)after admission,persistent intracranial hypertension after admission and serum TLR7 mRNA level were the risk factors of pulmonary infection in patients with HCH(P＜0.05).The area under the curve(AUC)and sensitivity of the combined detection of TLR7 mRNA,IL-23 and IL-17 to predict concurrent pulmonary infection in patients with HCH were higher than that of the three indicators alone(P＜0.05).The sen-sitivity of IL-17 was higher than that of TLR7 and IL-23(P＜0.05).The specificity of combined detection was higher than that of TLR7 and IL-17(P＜0.05).CONCLUSION The risk factors of concurrent pulmonary infection in patients with HCH were smoking history,chronic obstructive pulmonary disease,GCS score at admission,per-sistent intracranial hypertension after admission and serum TLR7 mRNA.At the same time,the combination of TLR7 mRNA,IL-23 and IL-17 had a good predictive value for concurrent pulmonary infection in patients with HCH.
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