Association of human papillomavirus 16/18 infection with positive rates of TLR4,STAT3 and MCM7 in breast cancer patients
OBJECTIVE To investigate the association of human papilloma virus 16/18(HPV 16/18)infection with the positive rates of toll-like receptor 4(TLR4),signal transduction factor and transcriptional activator 3(STAT3)and microchromosome maintenance protein 7(MCM7)in breast cancer patients.METHODS Totally 124 breast cancer patients admitted to Linyi Branch of Yuncheng Central Hospital and Salt Lake Branch of Shanxi Medical University First Hospital from Dec.2021 to Jul.2023 were retrospectively selected as the study group,and they were divided into the infected group(59 cases)and the uninfected group(65 cases)according to HPV 16/18 infection,and 127 patients with benign breast disease with the excision of the normal breast tissues around the lesions admitted in the same hospital during the same period were selected as the control group.The relation-ship between HPV 16/18 infection and clinicopathological features was analyzed,and the positive expressions of tissue TLR4,STAT3 and MCM7 were detected by immunohistochemistry.The positive expression of tissue TLR4,STAT3 and MCM7 in the study group and the control group were compared.The positive expressions of tissue TLR4,STAT3 and MCM7 in the infected and the uninfected groups were compared.Spearman method was used to analyze the correlation between HPV 16/18 infection and positive expression of TLR4,STAT3 and MCM7 in breast cancer patients.RESULTS HPV 16/18 infection in breast cancer patients was associated with tumor stage and lymph node metastasis(P＜0.05).The positive expression rates of tissue TLR4,STAT3 and MCM7 in the study group were significantly higher than those in the control group(P＜0.05).The positive expression rates of tissue TLR4,STAT3 and MCM7 in the infected group were significantly higher than those in the uninfected group(P＜0.05).Spearman correlation analysis showed that positive expression of TLR4,STAT3 and MCM7 were positively correlated with HPV 16/18 infection in breast cancer patients(r=0.703,0.739,0.752,P＜0.05).CONCLUSION HPV 16/18 infection in breast cancer patients was associated with tumor staging and lymph node metastasis,and the rate of positive expression of TLR4,STAT3 and MCM7 increased after infection,and the positive expression of TLR4,STAT3 and MCM7 was closely and positively correlated with HPV 16/18 infection in breast cancer patients.
Breast cancerHuman papilloma virusToll-like receptor 4Signal transduction factor and transcrip-tional activator 3Microchromosome maintenance protein 7
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