Pathogenic bacteria in patients with severe acute pancreatitis complicated with abdominal infection and the predictive value of sRAGE,Ghrelin and MCP-1
OBJECTIVE To analyze the pathogenic bacteria in patients with severe acute pancreatitis complicated with abdominal infection and the predictive value of soluble receptor for advanced glycation end(sRAGE),growth hormone releasing peptide(Ghrelin)and monocyte chemokine protein-1(MCP-1).METHODS Totally 186 pa-tients with severe acute pancreatitis admitted to the People's Hospital from Jan.2021 to Jan.2023 were included in the study and were divided into the intraperitoneal infection group(55 cases)and non-intraperitoneal infection group(131 cases)according to their complicity with intraperitoneal infection.The pathogenic bacteria in patients with severe acute pancreatitis complicated with abdominal infection were analyzed,serum sRAGE,Ghrelin and MCP-1 levels were compared between the two groups and patients with different levels of infection,and receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of sRAGE,Ghrelin and MCP-1 a-lone and in combination.RESULTS In 55 patients with severe acute pancreatitis complicated with abdominal infec-tion,a total of 68 strains of pathogenic bacteria were isolated and co-cultured,34 of which were gram-negative bacteria,24 were gram-positive bacteria,and 10 were fungi,with Klebsiella pneumoniae and Enterococcus faeci-um being predominant.The serum levels of sRAGE,Ghrelin and MCP-1 in the intraperitoneal infection group were higher than those in the non-intraperitoneal infection group(P＜0.05).Serum levels of sRAGE,Ghrelin and MCP-1 in patients with severe acute pancreatitis complicated with abdominal infection were higher than those in patients with mild to severe infection(P＜0.05).Intraperitoneal infection was included as positive and non-intrap-eritoneal infection as negative.ROC curve was plotted,and the area under the curve(AUC)of sRAGE,Ghrelin,MCP-1 alone and combined detection for predicting concomitant abdominal infections in patients with severe acute pancreatitis were 0.748,0.726,0.715,and 0.941,respectively,and the combined detection had the highest diag-nostic value.CONCLUSION Patients with severe acute pancreatitis had a higher risk of concurrent abdominal infec-tion.Serum sRAGE,Ghrelin and MCP-1 expressions increased with the occurrence and progression of infection,and combined detection was helpful for the diagnosis of concurrent abdominal infection in patients with severe a-cute pancreatitis.
Severe acute pancreatitisAbdominal infectionReceptor for end products of soluble glycosylationGrowth hormone releasing peptideMonocyte chemokine protein-1Predictive value
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