Association of infection-induced inflammatory markers and FC-γRIIA gene polymorphism with prognosis in patients with multiple myeloma during chemotherapy
OBJECTIVE To investigate the association of inflammatory index of infection and FCγRIIA gene poly-morphism with prognosis of multiple myeloma patients during chemotherapy.METHODS Clinical data of 55 pa-tients with multiple myeloma infected during chemotherapy(the study group)and 65 patients without infection during chemotherapy(the control group)admitted to Qilu Hospital of Shandong University(Qingdao)from Jan.2020 to Feb.2023 were retrospectively analyzed,and the patients in the study group were divided into a good prognosis group(29 cases)and a poor prognosis group(26 cases)according to prognosis.The NLR,MLR,PLR,serum PCT and gene polymorphisms of FC-γRIIA in venous blood were detected.RESULTS The NLR,MLR,PLR,PCT in venous blood of the study group were higher than those of the control group.The NLR,MLR,PLR and serum PCT in venous blood of the poor prognosis group were higher than those of the good prognosis group(P＜0.05).The FC-RIIA-R type in the study group was higher than that in the control group,while the FC-RIIA-H type was lower than that in the control group(P＜0.05).The percentage of FC-γRIIA-R type in the poor prog-nosis group was higher than that in the good prognosis group,while the percentage of FC-RIIA-H type was lower than that in the good prognosis group(P＜0.05).CONCLUSION Infection and poor prognosis of patients with multiple myeloma during chemotherapy were associated with abnormally elevated levels of NLR,MLR,PLR in venous blood and serum PCT,and the polymorphism of FC-γRIIA gene was significantly associated with infection and poor prognosis of patients with multiple myeloma during chemotherapy.
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