Pathogenic bacteria of intrauterine pneumonia in newborns and diagnostic value of LPS,SAA and PCT
OBJECTIVE To investigate the pathogenic bacteria of neonatal intrauterine pneumonia and the diagnostic value of lipopolysaccharide(LPS),amyloid A(SAA),and procalcitonin(PCT).METHODS Totally 96 cases of mothers who delivered in Ningbo Mingzhou Hospital and their newborns with intrauterine infectious pneumonia from Feb.2021 to Jan.2023 were retrospectively selected as the infection group,and the 124 cases of mothers who delivered in the hospital during the same period and their newborns without intrauterine infectious pneumonia were selected as the non-infection group,the pathogenic bacteria of the newborns with intrauterine infectious pneumonia were counted,the levels of serum lipopolysaccharide(LPS),amyloid A(SAA)and procalcitonin(PCT)were compared between the two groups,and the risk factors for neonatal intrauterine infection pneumonia were ana-lyzed,and the diagnostic value of serum laboratory indicators for neonatal intrauterine infection pneumonia was analyzed by using receiver's operating characteristics(ROC)curve.RESULTS Klebsiella pneumoniae,Pseudo-monas aeruginosa,Staphylococcus aureus and Staphylococcus epidermidis were the main pathogens of neonatal infection with infectious pneumonia.The levels of LPS,SAA and PCT in the infection group were higher than those in the non-infecrion group(P＜0.05).Intrauterine distress,premature rupture of membranes,long time from fetal delivery to rupture of membranes,maternal prenatal fever,maternal gestational diabetes mellitus were all independent risk factors for neonatal intrauterine pneumonia(P＜0.05).The area under the curve(AUC)value and sensitivity of serum LPS,SAA and PCT combined detection for intrauterine pneumonia in neonates were higher than those of the three detection alone(P＜0.05).CONCLUSION Klebsiella pneumoniae,Pseudomonas aeruginosa,Staphylococcus aureus and Staphylococcus epidermidis were the main pathogens of intrauterine in-fectious pneumonia in newborns,which could cause elevated levels of serum LPS,SAA and PCT,with a large number of susceptible factors,and the combination of serum LPS,SAA and PCT could improve the diagnostic value of neonatal intrauterine infection pneumonia.
Intrauterine infectious pneumoniaNewbornPathogenic bacteriaPredisposing factorLipopolysac-charideSerum amyloid AProcalcitoninDiagnostic value
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