Association of gestational pathogens infections,polymorphisms of folic acid metabolism-related genes with embryonic arrest
OBJECTIVE To investigate the association of gestational pathogens infections,polymorphisms of folic acid metabolism-related genes with embryonic arrest.METHODS A total of 102 pregnant women with embryonic arrest(recorded as the embryonic arrest group)who were admitted to the Antenatal Care Department of Huai'an Maternal and Child Health Hospital from October 2021 to December 2022,and 45 pregnant womenwho received routine pregnancy and antenatal care in the same hospital during the same period(with no adverse pregnancy out-come,recorded as the control group)were selected as the research subjects.Pathogens and polymorphisms of folic acid metabolism-related genes in the two groups were detected,and their association with embryonic arrest was analyzed.RESULTS The immunoglobulin M(IgM)positive rates of rubella virus and cytomegalovirus in the em-bryonic arrest group were higher than those in the control group(P＜0.05).The frequencies of TT genotype and T allele of folic acid metabolism-related gene MTH-FR C677T,CC genotype and C allele of MTH-FR A1298C,and G allele of MTRR A66G in the embryonic arrest group were higher than those in the control group(P＜0.05).TT genotype and T allele of MTH-FR C677T,CC genotype and C allele of MTH-FR A1298C,and G allele of MTRR A66G were related to the occurrence of embryonic arrest(P＜0.05).The MTH-FR C677T dominant mod-el and the MTRR A66G dominant model were related to embryonic arrest(P＜0.05).Pathogenic bacterial infec-tion(IgM positive rates of rubella virus and cytomegalovirus)and polymorphisms of folic acid metabolism-related loci(MTH-FR C677T and MTRR A66G)were risk factors for embryonic arrest(P＜0.05).CONCLUSION Etiol-ogy and polymorphisms of folic acid metabolism-related genes(MTH-FR C677T and MTRR A66G)are related to embryonic arrest.The risk of developing embryonic arrest can be assessed by pre-pregnancy testing for polymor-phisms of folic acid metabolism-related genes and pathogenic bacterial infection.
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