Prevalence trends and clinical characteristics of common pathogens detected by mNGS in a general hospital from 2019 to 2023
OBJECTIVE To analyze the clinical application value of metagenomics next generation sequencing(mNGS)in the screening and detection of epidemic pathogens in Hunan province,and to analyze the prevalence trends and clinical characteristics of different epidemic pathogens.METHODS The data of patients underwent mNGS pathogen detection in central China were collected and sorted out,the high-frequency detected pathogens were counted,and the prevalence trend and susceptibility characteristics were analyzed and tracked.RESULTS A total of 16 627 people were counted for common epidemic pathogens from 2019 to 2023,including 10 811 males(65.02％)and 5 816 females(34.98％).The pathogens detected at high frequency were SARS-COVID-19,her-pesvirus(type 1/4/5),Acinetobacter baumannii,Candida albicans,Pneumocystis yerinii,Enterococcus faeci-um,Klebsiella pneumoniae,Aspergillus fumigatus,Pseudomonas aeruginosa,Mycobacterium tuberculosis con-comitants,Corynebacterium striatum,Streptococcus pneumoniae,Mycoplasma pneumoniae,Chlamydia pecti and Bacillus coli.Starting from the fourth quarter of 2021,samples tested for pathogens were increased year by year,with the department of respiratory,intensive care,infectious disease,and pediatrics showing higher accept-ance of mNGS.CONCLUSION The mNGS could shorten the time of pathogen detection,improve the rate and ac-curacy of pathogen identification,and could be used as an application to guide preventive epidemiology.
PathogenEpidemic trendMetagenomics next generation sequencingHumanSARS-CoV-2Hu-man herpesvirusAcinetobacter baumannii
NETL
NSTL
万方数据
