Drug resistance of pathogenic bacteria and risk factors for central venous catheter-associated bloodstream infections in a tomour hospital
OBJECTIVE To investigate the drug resistance of pathogenic bacteria and risk factors for central venous catheter-associated bloodstream infections in an oncology hospital.METHODS The data of 299 patients with cen-tral venous catheters in the Fourth Hospital of Heibei Medical University from Jan.2019 to Dec.2022 were col-lected,the distribution of pathogens and results of drug sensitivity test for the patients with central venous cathe-ter related bloodstream infections were observed,and the risk factors were analyzed.RESULTS The survey found that eighty-four patients had CRBSI,with a 1000-day infection rate of 0.08％0.The unit with the highest number of infections was ICU.A total of 88 strains of pathogenic bacteria were co-cultured and isolated,of which 51 strains of gram-negative bacteria accounted for 57.95％,31 strains of gram-positive bacteria accounted for 35.23％,and the top 5 strains detected were Klebsiella pneumoniae,Pseudomonas aeruginosa,Sta phycococcus hominis,Staphylococcus epidemidis and Enterobacter cloacae,and the main pathogenic bacteria had a high re-sistant rate to antibiotics such as penicillin,cephalosporin,erythromycin and quinolones.Catheterization time,di-abetes levels were the independent risk factors for CRBSI and albumin was a protective factor for CRBSI(P＜0.05).CONCLUSION The pathogenic bacteria causing the occurrence of CRBSI were mainly gram-negative bacteria and had a high rate of drug resistance,therefore,the clinic should be more vigilant,and at the same time,effective preventive and control measures should be taken for patients with high risk factors in order to prevent the occurrence of CRBSI.
Central vein catheterizationCatheter related bloodstream infectionPathogenic bacteriaDrug resist-anceRisk factorTomour hospital
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