目的 探讨幽门螺杆菌(Hp)感染与血清同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)及维生素水平的相关性.方法 回顾性分析2019年1月-2021年11月在解放军总医院第二医学中心健康医学科进行健康体检人群的体检指标,将Hp感染者设为感染组,未感染者设为对照组;采用多因素Logistic回归模型分析Hp感染与性别、年龄、体质量指数(BMI)及Hcy、hs-CRP和维生素水平的相关性.结果 Hp感染者hs-CRP、Hcy水平高于对照组(P＜0.05);感染组叶酸、维生素A、维生素B12、维生素B6、维生素C、维生素D3水平低于对照组(P＜0.05);调整性别、年龄、hs-CRP、Hcy、叶酸及维生素等因素后,多因素Logistic回归模型结果发现:以女性为参照,男性 Hp 感染的患病风险升高(OR=1.290),年龄(OR=1.049)、hs-CRP(OR=3.678)、Hcy(OR=1.140)、维生素B12(OR=1.211)与Hp感染率呈正相关;叶酸(OR=0.807)、维生素A(OR=0.171)、维生素B6(OR=0.870)、维生素C(OR=0.858)、维生素E(OR=0.990)、维生素D3(OR=0.947)与Hp感染率呈负相关.结论 Hcy及hs-CRP水平升高,叶酸、维生素A、维生素B12、维生素B6、维生素C、维生素E、维生素D3降低与Hp感染感染率升高相关.
Correlation between Helicobacter pylori infection and serum vitamin level in health screening population
OBJECTIVE To investigate the relationship between Helicobacter pylori(Hp)infection and serum ho-mocysteine(Hcy),hypersensitive C-reactive protein(hs-CRP)and vitamin levels.METHODS The physical exam-ination indexes of people who underwent physical examination in the department of health medicine of the Second Medical Center of PLA General Hospital from Jan.2019 to Nov.2021 were retrospectively analyzed.The patients with Hp infection were assigned as the infection group,and the patients without infection were assigned as the control group.Multivariate logistic regression model was used to analyze the relationship between Hp infection and gender,age,body mass index(BMI),Hcy,hs-CRP,and vitamin levels.RESULTS The hs-CRP and Hcy levels in Hp-infected patients were higher than those in the control group(P＜0.05).The levels of folate,vitamin A,vitamin B12,vitamin B6,vitamin C,and vitamin D3 of the infection group were lower than those of the control group(P＜0.05).After adjusting for sex,age,hs-CRP,Hcy,folic acid and vitamins,the results of multivariate logistic regression modeling found that the prevalence risk of Hp infection was rised in males(OR=1.290)using female as the reference,and age(OR=1.049),hs-CRP(OR=3.678),Hcy(OR=1.140)and vitamin B12(OR=1.211),were positively correlated with the prevalence of Hp.Folic acid(OR=0.807),vitamin A(OR=0.171),vitamin B6(OR=0.870),vitamin C(OR=0.858),vitamin E(OR=0.990),and vitamin D3(OR=0.947)were negatively correlated with the prevalence of Hp.CONCLUSION Elevated levels of Hcy and hs-CRP,and reduced folate,vitamin A,vitamin B12,vitamin B6,vitamin C,vitamin E,and vitamin D3 were associated with an increased prevalence of Hp infection.
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