Construction of a differential diagnostic model for pyogenic and non-pyogenic spinal infections based on erythrocyte sedimentation rate and white blood cell with disease duration
OBJECTIVE To construct a differential diagnostic model for pyogenic spinal infection(PSI)and non-py-ogenic spinal infection(NPSI)based on C-reactive protein,erythrocyte sedimentation rate,and blood routine indi-cators.METHODS Totally 158 suspected spinal infection patients admitted to Xiangya and Xiangya Boai Hospital from Jan.2019 to Sep.2022 were collected as the study subjects,and they were divided into a PSI group(87 ca-ses)and a non PSI group(71 cases)according to pathological identification results.Clinical data of the two groups were analyzed,and the differences in various indicators between the two groups were compared.C-reactive pro-tein,erythrocyte sedimentation rate,and disease course were screened to develop a diagnostic model,receiver op-erating characteristic(ROC)curves were plotted to evaluated the diagnostic value of the model.RESULTS There were statistically significant differences in C-reactive protein,erythrocyte sedimentation rate,white blood cell count,red blood cell count,hemoglobin,neutrophils,neutrophil percentage,monocyte percentage,and disease course between the two groups(P＜0.05);Through logistic regression,the three indicators of red blood cell sed-imentation rate,white blood cell count,and disease course were screened to establish a joint diagnostic model,which had an area under the ROC curve(AUC)of 0.802,a sensitivity of 0.678,and a specificity of 0.845.CONCLUSION The joint diagnostic model established by red blood cell sedimentation rate,white blood cell count,and disease course can assist in differentiating pyogenic and non-pyogenic spinal infections,which can better guide the clinic and improve the prognosis of patients with timely and targeted treatment.
Pyogenic spinal infectionsC-reactive proteinErythrocyte sedimentation rateDisease courseDiag-nostic value
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