Diagnostic value of heat shock protein 10 combined with MRI in thoracolumbar spinal tuberculosis
OBJECTIVE To investigate the diagnostic value of Mycobacterium tuberculosis heat shock protein 10(Hsp10)combined with magnetic resonance imaging(MRI)in thoracolumbar spinal tuberculosis.METHODS A total of 95 patients with suspected thoracolumbar tuberculosis who attended the clinic between Jan.2013 and May 2021 were selected and underwent serum Mycobacterium tuberculosis Hsp10 detection and MRI examination.76 cases of thoracolumbar tuberculosis confirmed by pathological examination were set up as the tuberculous group,and 19 cases of spinal metastasis were set up as the metastasis group.Serum Mycobacterium tuberculosis Hsp10 levels,time-signal curve characteristics of MRI,volume transfer constant(Ktrans),and rate constants(Kep)were compared between the two groups,and their diagnostic value was analyzed.RESULTS Serum Mycobacterium tuberculosis Hsp10 level in the tuberculosis group was higher than that in the metastasis group(P＜0.05).The MRI time-signal curves of the tuberculosis group were:44.74％of the continuously ascending type,48.68％of the ascending plateau type,and 6.58％of the fast-entry-fast-exit type;the MRI time-signal curves in the metasta-sis group were 21.05％of the continuously ascending type,31.58％of the ascending plateau type,and 47.37％of the fast-entry-fast-exit type,with statistically significant differences between the two groups(P＜0.05).The Ktrans and Kep in the tuberculosis group were lower than those in the metastasis group(P＜0.05).The Kappa value of serum Mycobacterium tuberculosis Hsp10 were 0.573,with an accuracy rate of 85.26％.The Kappa val-ue of MRI were 0.731,with an accuracy rate of 90.53％.The Kappa value of MRI combined with serum Myco-bacterium tuberculosis Hsp10 were 0.817,with an accuracy rate of 93.68％.CONCLUSION Hsp10 combined with MRI could improve the diagnostic accuracy for thoracolumbar spinal tuberculosis.
Magnetic resonance imagingHeat shock protein 10Thoracolumbar vertebral bodyMycobacterium tuberculosisDiagnosis
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