Association of nucleotide-binding oligomerization domain-like receptor-mediated inflammatory factors with cervical cancer caused by HPV
OBJECTIVE To investigate the association of nucleotide-binding oligomerization domain(NOD)-like re-ceptor-mediated inflammatory factor expressions with human papillomavirus(HPV)-associated cervical cancer.METHODS Totally 120 patients with cervical lesions admitted to Xingtai People's Hospital from Jan.2022 to Jan.2023 were selected,including 60 cases of benign lesions and 60 cases of malignant lesions.All patients underwent hysterectomy,and cervical cancer tissue and benign cervical tissue were obtained during the surgery,and the ex-pression of NOD1 and NOD2 mRNA in cervical tissues,as well as the expression levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6 and IL-18 protein were detected.The expression levels of inflammatory factors in benign lesions and malignant lesions were compared,and the relationship between the expression levels of inflammatory factors and cervical cancer grade and high-risk human papillomavirus(HR-HPV)infection was analyzed.RESULTS The expression levels of NOD1 and NOD2 mRNA and TNF-α,IL-1β,IL-6 and IL-18 protein in patients with malignant lesions were significantly higher than those in patients with benign lesions(P＜0.05).With the increase of the degree of cervical cancer grading,the expression levels of NOD1 and NOD2 mRNA and TNF-α,IL-1β,IL-6 and IL-18 protein in patients with cervical cancer showed an increasing trend,and the differ-ences in the expression levels of NOD-like receptor-mediated related inflammatory factors in patients with gradeⅠ-Ⅲ were statistically significant(P＜0.05).Among the 60 patients with malignant lesions enrolled in the group,there were 40 cases of HR-HPV infection,of which the expression levels of NOD1 and NOD2 mRNA and TNF-a,IL-1β,IL-6 and IL-18 protein in HR-HPV-positive patients were significantly higher than those in HR-HPV-negative patients(P＜0.05).CONCLUSION The occurrence of cervical cancer was closely related to the per-sistent infection of HR-HPV,which mediated the expression of NOD-like receptors mediating related inflammato-ry factors,and thus participated in the development of cervical cancer.
Nucleotide binding oligomerization domainInflammatory factorsHuman papillomavirusInfectionCervical cancer
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