Association of CDKN2A single nucleotide gene polymorphism in patients with gestational diabetes mellitus combined with HBV infection
OBJECTIVE To investigate the single nucleotide polymorphism of cell cycle dependent kinase inhibitor gene(CDKN2A)in patients with gestational diabetes mellitus combined with hepatitis B virus(HBV)infection and their liver function.METHODS Totally 106 patients with gestational diabetes mellitus complicated with HBV infection admitted to Wuxi People's Hospital from May 2019 to Jan.2022 were selected as the study group,and 115 patients with gestational diabetes mellitus without HBV infection were selected as the control group.The CD-KN2A gene distribution,allele frequency,liver function,immune function,pancreatic islet β Cell function,preg-nancy outcomes of pregnant women,and incidence of neonatal complications between the two groups were com-pared.RESULTS The frequencies of CDKN2A TT genotype and T allele in the study group were higher than those in the control group(P＜0.05).The levels of peripheral blood CD3+,CD,+,CD,+/CD8+and β cell function in-dex(HOMA-β)in the study group were lower than those in the control group.The levels of serum alanine amin-otransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil),total bile acid(TBA),peripheral blood immunoglobulin M(IgM),IgA,and insulin resistance index(HOMA-IR)in the study group were higher than those in the control group(P＜0.05).The incidence of adverse pregnancy outcomes in the study group was higher than that in the control group.The incidence of neonatal complications was higher than that in the control group(P＜0.05).CONCLUSION The CDKN2A TT genotype and T allele in patients with gestational diabetes were closely related to HBV infection,and HBV infection exacerbated hepatic impairment,worsened the immune dysfunction and insulin resistance,and increased the risk of adverse pregnancy outcomes and neonatal complica-tions.
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