Expressions of serum NT-proBNP,PCT and oxidative stress injury indexes in septic shock patients with myocardial injury and their significance
OBJECTIVE To observe the expressions of serum N-terminal pro-brain natriuretic peptide(NT-proB-NP),procalcitonin(PCT)and oxidative stress injury indexes in the septic shock patients with myocardial injury and analyze the significance.METHODS A total of 103 patients with septic shock who were treated in Longyou County People's Hospital from Jan 2019 to Jan 2023 were enrolled in the study and were divided into the myocar-dial injury group with 46 cases and the non-myocardial injury group with 57 cases according to the status of com-plication with myocardial injury.The levels of serum NT-proBNP,PCT,oxidative stress injury indexes superox-ide dismutase(SOD),malondialdehyde(MDA),advanced oxidation protein product(AOPP)and glutathione peroxidase(GSH-Px)were compared between the two groups,the cardiac function indexes were compared be-tween the two groups,and the values of serum NT-proBNP,PCT and oxidative stress injury indexes in diagnosis of myocardial injury of the patients with septic shock.RESULTS The New York Heart Disease Association(NY-HA)grade,serum NT-proBNP,PCT,MDA and AOPP levels of the myocardial injury group were significantly higher than those of the non-myocardial injury group(P＜0.05);the levels of SOD and GSH-Px of the myocardial injury group were significantly lower than those of the non-myocardial injury group(P＜0.05).The early diastolic velocity to atrial contraction velocity(E/A),cardiac output(CO),cardiac index(CI)and left ventricular ejection fraction(LVEF)were significantly lower in the myocardial injury group than in the non-myocardial injury group(P＜0.05).With the uprising of NYHA grade the levels of serum NT-proBNP,PCT,MDA and AOPP of the septic shock patients complicated with myocardial injury were elevated significantly(P＜0.05),while the levels of SOD and GSH-Px were reduced significantly(P＜0.05).The area under curves(AUCs)of the serum NT-proB-NP,PCT,SOD,MDA,AOPP,GSH-Px and the joint detection of the above indexes were respectively 0.888,0.830,0.795,0.860,0.881,0.806 and 0.955 in diagnosis of the myocardial injury of the septic shock patients.CONCLUSION The myocardial injury of the septic shock patients is significantly associated wih the serum NT-proBNP,PCT and oxidative stress injury indexes,to which the hospital should attach great importance.
NETL
NSTL
万方数据
