Relationship between Helicobacter pylori and severity of carotid atherosclerosis stenosis,serum Lp-PLA2,MMP-9 and visfatin
OBJECTIVE To explore the relationship between Helicobacter pylori and degree of carotid atherosclero-sis stenosis,serum lipoprotein-associated phospholipase A2(Lp-PLA2),matrix metalloproteinase-9(MMP-9)and visfatin.METHODS A total of 89 patients with carotid atherosclerosis who were treated in Huaihe Hospital of Henen University from Jul 2021 to Jul 2023 were recruited as the research subjects and were divided into the infec-tion group with 28 cases and the non-infection group with 61 cases according to the status of Hp infection.The pa-tients were divided into the mild stenosis group with 25 cases,the moderate stenosis group with 31 cases and the severe stenosis group according to the result of carotid artery ultrasound examination.The levels of serum Lp-PLA2,MMP-9 and visfatin were compared between the infection group and the non-infection group as well as a-mong the patients with different severities of stenosis.Spearman analysis was performed for the association be-tween the Hp infection and the severity of carotid atherosclerosis stenosis,serum Lp-PLA2,MMP-9 and visfatin.RESULTS The levels of serum Lp-PLA2,MMP-9 and visfatin of the moderate stenosis group and the severe ste-nosis group were significantly higher than those of the mild stenosis group,and the levels of above indexes of the severe stenosis group were significantly higher than those of the moderate stenosis group(P＜0.05).The percent-age of Hp-positive patients of the severe stenosis group was significantly higher than that of the mild stenosis group(P＜0.05).The Hp infection was positively correlated with the severity of stenosis assessed by the ultra-sound examination(P＜0.05).The levels of serum Lp-PLA2,MMP-9 and visfatin of the infection group were sig-nificantly higher than those of the non-infection group(P＜0.05).The Hp infection was positively correlated with the levels of serum Lp-PLA2,MMP-9 and visfatin of the patients with carotid atherosclerosis(P＜0.05).CONCLUSION The carotid atherosclerosis patients with Hp infection show high expression levels of serum Lp-PLA2,MMP-9 and visfatin.There is association between the Hp infection and the severity of stenosis,the Lp-PLA2,MMP-9 and visfatin of the patients with carotid atherosclerosis.
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