Influence of PICC-related bloodstream infection on peripheral blood T lymphocyte subsets and TGF-β1/Smads signaling pathways of gastric cancer patients undergoing chemotherapy
OBJECTIVE To observe the influence of peripherally inserted central catheter(PICC)-related blood-stream infection(CRBSI)on peripheral blood T lymphocyte subsets and transforming growth factor-β1(TGF-β1)/signal transduction protein Smads(Smads)signaling pathways of the gastric cancer patients undergoing chemotherapy.METHODS Totally 108 gastric cancer patients who were treated with PICC and underwent chemo-therapy in Huanggang Central Hospital from Oct 2020 to Oct 2023 were recruited as the research subjects and were divided into the infection group with 31 cases and the no infection group with 77 cases according to the status of CRBSI.The levels of peripheral blood inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin(IL)-1β],peripheral blood T lymphocytes subsets(CD3+,CD4+,CD8+and CD,4/CD8+)and expression levels of TGF-β1/Smads signaling pathway-related proteins and mRNA(TGF-β1,Smad3 and Smad2)were observed and compared between the two groups.Pearson correlation analysis was performed for the association between the CD3+,TGF-β1 proteins and the inflammatory factors of the gastric cancer and chemotherapy patients with CRB-SI.RESULTS The levels of TNF-α,IL-1β,CD8+and the expression levels of TGF-β1,Smad3,Smad2 proteins and mRNA were higher in the infection group than in the no infection group,while the levels of CD3+,CD4+and CD4+/CD8+of the infection group were lower than those of the no infection group(P＜0.05).The result of Pear-son correlation analysis showed that the TGF-β1 of the gastric cancer and chemotherapy patients with PICC-related bloodstream infection was positively correlated with TNF-α and IL-1β(P＜0.05),while the CD3+was negatively correlated with TNF-α and IL-1β(P＜0.05).CONCLUSION The PICC-related bloodstream infection may lead to the imbalance of peripheral blood T lymphocyte subsets and activation of TGF-β1/Smads signaling pathways of the gastric cancer patients undergoing chemotherapy and affect the immune state of the patients.
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