Pathogens isolated from hepatitis B cirrhosis patients complicated with spontaneous bacterial peritonitis and risk factors for prognosis
OBJECTIVE To investigate the pathogens isolated from the hepatitis B cirrhosis patients complicated with spontaneous bacterial peritonitis(SBP)and analyze the risk factors for prognosis.METHODS Totally 168 hepatitis B cirrhosis patients complicated with SBP who were treated in Qingdao Traditional Chinese Medicine Hospital from Jan 2019 to May 2022 were recruited as the research subjects and were respectively assigned as the poor prognosis group(death)with 53 cases and the favorable prognosis group with 115 cases based on death as the determined end point for prognosis according to the treatment outcomes within 1 year.The clinical data were retrospectively collected from the patients,the etiological characteristics of the hepatitis B cirrhosis patients com-plicated with SBP were analyzed,and logistic regression analysis was performed for the treatment outcomes of the hepatitis B cirrhosis patients complicated with SBP.RESULTS Totally 189 strains of pathogens were isolated from the 168 hepatitis B cirrhosis patients complicated with SBP,73.02％of which were gram-negative bacteria(domi-nated by Escherichia coli),and 26.98％were gram-positive bacteria(dominated by Staphylococcus epiderm idis).There were 53 cases of poor treatment outcomes within 1 year,and the rate of poor treatment outcomes was 31.55％.The result of multivariate logistic analysis showed that prolonged ascites,albumin-bilirubin(ALBI)score,Child-Pugh score and rise of neutrophil counts and procalcitonin(PCT)in ascites were the risk factors for the poor treatment outcomes of the hepatitis B cirrhosis patients complicated with SBP(P＜0.05).CONCLUSION The gram-negative bacteria are dominant among the pathogens isolated form the hepatitis B cirrhosis patients com-plicated with SBP.There are a variety of risk factors for the treatment outcomes.It is necessary to screen out the high-risk factors based on the risk factors so as to develop prevention measures.
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