首页|ICU重症颅脑损伤术后肺部感染病原菌与血清HMGB1、ICAM-1、miR-126、miR-16表达及其意义

ICU重症颅脑损伤术后肺部感染病原菌与血清HMGB1、ICAM-1、miR-126、miR-16表达及其意义

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目的 探究重症监护室(ICU)重症颅脑损伤术后肺部感染病原菌与血清高迁移率族蛋白B1(HMGB1)、细胞间黏附分子-1(ICAM-1)、微小核糖核酸(miR)-126、miR-16表达及其意义.方法 选取2022年1月-2023年1月中国医科大学附属盛京医院收治的ICU重症颅脑损伤95例患者为研究对象,根据术后肺部感染情况分为感染组34例、非感染组61例.比较两组血清HMGB1、ICAM-1、miR-126、miR-16水平,统计感染组病原菌分布,分析HMGB1、ICAM-1、miR-126、miR-16对ICU重症颅脑损伤术后肺部感染的预测价值.结果 感染组共检出45株病原菌,革兰阴性菌占比最高,以肺炎克雷伯菌为主.感染组血清miR-126水平较非感染组低,血清HMGB1、ICAM-1、miR-16水平较非感染组高(P＜0.05),四指标联合检测诊断ICU重症颅脑损伤术后肺部感染的曲线下面积(AUC)比各指标单一检测均高(P＜0.05),敏感度为91.18％、特异度为88.52％.结论 ICU重症颅脑损伤术后肺部感染多为革兰阴性菌感染,血清HMGB1、ICAM-1、miR-16水平高表达、miR-126水平低表达,联合检测可提高其预测价值.
Pathogens causing postoperative pulmonary infections and expressions of serum HMGB1,ICAM-1,miR-126 and miR-16 in ICU patients with severe craniocerebral injury
OBJECTIVE To explore the pathogens causing postoperative pulmonary infection and expressions of ser-um high mobility group protein B1(HMGB1),intercellular adhesion molecule-1(ICAM-1),microribonucleic acid(miR)-126 and miR-16 in intensive care unit(ICU)patients with severe craniocerebral injury and analyze the sig-nificance.METHODS A total of 95 patients with severe craniocerebral injury who were treated in ICU of Shengjing Hospital Affiliated to China Medical University from Jan 2022 to Jan 2023 were recruited as the research subjects and were divided into the infection group with 34 cases and the non-infection group with 61 cases according to the status of pulmonary infection.The levels of serum HMGB1,ICAM-1,miR-126 and miR-16 were compared be-tween the two groups.The distribution of pathogens isolated from the infection group was statistically analyzed.The values of HMGB1,ICAM-1,miR-126 and miR-16 in prediction of postoperative pulmonary infection in the ICU patients with severe craniocerebral injury were analyzed.RESULTS Totally 45 strains of pathogens were isola-ted from the infection group,among which gram-negative bacteria were dominant,and Klebsiella pneumoniae was the predominant species.The serum miR-126 level of the infection group was lower than that of the non-infec-tion group,while the levels of serum HMGB1,1CAM-1 and miR-16 of the infection group were higher than those of the non-infection group(P＜0.05).The area under curve(AUC)of the joint detection of the four indexes was higher than that of the single index in diagnosis of the postoperative pulmonary infection of the ICU patients with severe craniocerebral injury(P＜0.05),with the sensitivity 91.18％,the specificity 88.52％.CONCLUSION The patients with gram-negative bacteria infections are dominant among the ICU severe craniocerebral injury patients with postoperative pulmonary infection,the patients show the high expression levels of serum HMGB1,ICAM-1 and miR-16 and the low expression level of miR-126.The joint detection may raise the predictive value.

Intensive care unitSevere craniocerebral injuryPulmonary infectionPathogenHigh mobility group protein B1Intercellular adhesion molecule-1Microribonucleic acidReceiver operating characteristic curveDi-agnostic value

刘爽、王晶、王睿、王微

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中国医科大学附属盛京医院重症监护病房,辽宁沈阳 110000

中国医科大学附属盛京医院护理部,辽宁沈阳 110000

重症监护室 重症颅脑损伤 肺部感染 病原菌 高迁移率族蛋白B1 细胞间黏附分子-1 微小核糖核酸 受试者工作特征曲线 诊断价值

国家自然科学基金资助项目

81701886

2024

10.11816/cn.ni.2024-231647

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心
影响因子：1.885
ISSN：1005-4529
年,卷(期)：2024.34(13)
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