Expressions of serum miR-31-5p and miR-4286 in preeclampsia pregnant women complicated with Helicobacter pylori infection and their significance
OBJECTIVE To observe the expressions of serum microribonucleic acid-31-5p(miR-31-5p)and microri-bonucleic acid-4286(miR-4286)in the preeclampsia(PE)pregnant women complicated with Helicobacter pylori(Hp)infection and analyze the significance.METHODS A total of 198 PE pregnant women complicated with Hp infection who were treated in Handan Central Hospital from Jan 2022 to May 2023 were assigned as the study group,meanwhile,205 pregnant women with Hp infection were chosen as the control group.A follow-up was car-ried out till the delivery.The clinical data,pregnancy outcomes and expression levels of serum miR-31-5p and miR-4286 at the diagnosis of PE(T0),the first day of the 28th week of pregnancy(T1)and the first day of 30th week of pregnancy were observed and compared between the two groups;the expression levels of serum miR-31-5p and miR-4286 were compared among the PE pregnant women complicated with Hp infection with different pregnancy outcomes.The values of the single and joint detection of the indexes in prediction of poor pregnancy outcomes were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS The proportions of pregnant women with cesarean section,poor pregnancy outcomes were significantly higher in the study group than in the control group,and the gestational age of the study group was significantly shorter than that of the control group(P＜0.05).The serum miR-4286 level of the study group was significantly lower than that of the control group at T1 and T2,while the serum miR-31-5p level of the study group was significantly higher than that of the control group(P＜0.05).Among the PE pregnant women complicated with Hp infection,the expression level of serum miR-4286 of the poor pregnancy outcome group was significantly lower than that of the favorable pregnancy outcome group at the time points,while the expression level of serum miR-31-5p of the poor pregnancy outcome group was significantly higher than that of the favorable pregnancy outcome group(P＜0.05).The ROC curve a-nalysis showed that the area under curve(AUC)of the joint detection of the indexes was the highest(0.940)at the time points(P＜0.05),with the sensitivity 86.61％,the specificity 90.70％.CONCLUSION The PE pregnant women complicated with Hp infection show high expression level of serum miR-31-5p and low expression level of miR-4286.With the increase of gestational age,the expression level of serum miR-31-51p shows a downward trend,and the expression level of miR-4286 shows an upward trend.The joint detection of the indexes has high value in prediction of the poor pregnancy outcomes of the PE pregnant women complicated with Hp infection.
PreeclampsiaHelicobacter pyloriMicroribonucleic acid-31-5pMicroribonucleic acid-4286Preg-nancy outcomePredictive value
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