Clinical characteristics of gestational diabetes mellitus patients complicated with puerperal infection,distribution of pathogens and drug resistance
OBJECTIVE To explore the clinical characteristics of gestational diabetes mellitus(GDM)patients com-plicated with puerperal infection,distribution of pathogens and drug resistance.METHODS A total of 154 GDM patients complicated with puerperal infection who were treated in Nanning Maternal and Child Hospital from Jan 2020 to Dec 2022 were chosen as the study group,meanwhile,160 non-GDM patients with puerperal infection were chosen as the control group.The distribution of pathogens causing different sites of infections was compared.The distribution and drug resistance of the pathogens causing the puerperal infection were observed and compared between the two groups.RESULTS There were no significant differences in the clinical characteristics and infection sites between the two groups.Totally 322 strains of pathogens were isolated from the 314 patients with puerperal infection.There were no significant differences in the gram-positive bacteria and fungi between the two groups.The gram-negative bacteria of the study group were significantly more than those of the control group,and the Escherichia coli strains of the study group were significantly more than those of the control group(P＜0.05).The drug resistance rates of Staphylococcus aureus strains to cefradine,penicillin and ampicillin were more than 50％in the two groups;the drug resistance rate of the S.aureus strains to cefotaxime was significantly higher in the study group than in the control group(P＜0.05).The drug resistance rate of the Staphylococcus epidermidis strains to levofloxacin was more than 50％.The drug resistance rates of E.coli strains to penicillin,ceftazidime,norfloxacin,levofloxacin,amikacin and piperacillin were more than 50％in the two group.CONCLUSION The pu-erperal infection of the GMD patients is not associated with the factors such as baseline data and infection sites.The GDM may affect the characteristics of pathogens and drug resistance of the patients with puerperal infection and increase the incidence of gram-negative bacteria infections and the drug resistance to S.aureus.
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