Pathogenic bacteria isolated from children with neonatal necrotizing enterocolitis and risk factors
OBJECTIVE To explore the pathogens causing the neonatal necrotizing enterocolitis and analyze the risk factors.METHODS A total of 82 children who were diagnosed with neonatal necrotizing enterocolitis and were treated in the Affiliated Matern & Child Care Hospital of Nantong University from Jan 2018 to Dec 2022 were as-signed as the study group,meanwhile,82 neonates who did not have neonatal necrotizing enterocolitis were ran-domly chosen as the control group.The distribution,drug resistance of pathogens and the risk factors for the neo-natal necrotizing enterocolitis were statistically analyzed.RESULTS Totally 44 strains of pathogens were isolated from the 82 children with neonatal necrotizing enterocolitis,29(65.91％)of which were gram-negative bacteria,14(31.82％)were gram-positive bacteria,and 1(2.27％)was fungus.There were 11 strains of Klebsiella pneu-moniae that were resistance to amoxacillin and cefuroxime and no strain resistant to levofloxacin or ciprofloxacin;there were 11 strains of Escherichia coli that were resistant to amoxicillin,10 strains resistant to ampicillin-sul-bactam and no strain resistant to imipenem or piperacillin-tazobactam.Gestational diabetes mellitus,non-breast feeding,premature delivery,neonatal shock,premature rupture of fetal membrane,intrauterine distress and low birth weight were the risk factors for the neonatal necrotizing enterocolitis(P＜0.05).CONCLUSION The gram-negative bacteria are dominant among the pathogens causing the neonatal necrotizing enterocolitis.The K.pneu-moniae strains are sensitive to levofloxacin and ciprofloxacin;the E.coli strains were sensitive to imipenem and piperacillin-tazobactam.Gestational diabetes mellitus,non-breast feeding,premature delivery,neonatal shock,premature rupture of fetal membrane,intrauterine distress and low birth weight are the risk factors for the neo-natal necrotizing enterocolitis.
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