Influence of adjuvant therapy with Jianpi Qingre Decoction on liver function,immune function and serum HBsAg of patients with chronic hepatitis B
OBJECTIVE To explore the influence of adjuvant therapy with Jianpi Qingre Decoction on liver function,immune function and serum hepatitis B virus surface antigen(HBsAg)of the patients with chronic hepatitis B(CHB).METHODS Totally 110 patients with CHB of liver-spleen dampness heat syndrome who were treated in the Second People's Hospital of Linhai from Jan 2019 to Aug 2022 were recruited as the research subjects and were randomly divided into the control group and the study group,with 55 cases in each group.The control group was treated with oral administration of entecavir tablets and subcutaneous injection of polyethylene glycol interfer-on-α(Peg-IFN-α),while the study group was given additional Jianpi Qingre Decoction for adjuvant therapy on ba-sis of the treatment of the control group.Both groups were continuously treated for 3 months.The curative effect,scores of TCM syndromes,serum HBsAg,liver function indexes,immune function indexes and incidence of ad-verse reactions were observed and compared between the two groups.RESULTS The total effective rate of the study group was 87.27％,and there was no significant difference between the study group and the control group.The scores of dampness-heat obstruction,liver dysfunction,spleen dysfunction,nausea and abdominal distention of the study group was lower than those of the control group after the treatment(P＜0.05).The serum HBsAg level of the study group was lower than that of the control group after the treatment for 2 and 3 months(P＜0.05).The levels of alanine aminotransferase(ALT),γ-glutamyl transpeptidase(GGT),aspartate aminotrans-ferase(AST)and total bilirubin(TBIL)of the study group were lower than those of the control group after the treatment(P＜0.05).The levels of peripheral blood CD3+,CD4+and CD4+/CD8+T lymphocytes of the study group were higher than those of the control group,while the CD8+T lymphocyte level of the study group was low-er than that of the control group(P＜0.05).The incidence of adverse reactions of the study group was 12.73％,and there was no significant difference between the study group and the control group.CONCLUSION The adjuvant therapy with Jianpi Qingre Decoction can effectively reduce the level of serum HBsAg of the CHB patients and promote the recovery of cellular immune function and liver function,with the safety high.
Jianpi Qingre DecoctionChronic hepatitis BLiver functionImmune functionHepatitis B virus sur-face antigen
NETL
NSTL
万方数据
